Myosin head orientation: a structural determinant for the Frank-Starling relationship

Collaborative studies that combine non-crystalline x-ray diffraction with muscle mechanics provide important insights into the mechanism of the classic Frank-Starling relationship. Editor in Chief William C. Stanley and leading expert Richard L. Moss (University of Wisconsin) interview co-authors Pieter de Tombe (Loyola University Chicago) and Thomas Irving (Illinois Institute of Technology) about their innovative research collaboration and their quest to manipulate the contractile state of myofilaments, with implication for the failing heart.

Gerrie P Farman, David Gore, Edward J Allen, Kelly Q Schoenfelt, Thomas C. Irving, and Pieter P. de Tombe. Myosin head orientation: a structural determinant for the Frank-Starling relationship. Am J Physiol Heart Circ Physiol, published ahead of print April 1, 2011; doi:10.1152/ajpheart.01221.2010.

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Differential vascular dysfunction in insulin resistance

Two things are clear—there is a global epidemic in obesity, and physical exercise is an effective means to combat it. Listen as Editor in Chief William C. Stanley and expert Robert Hester(University of Mississippi) interview lead author Shawn Bender (University of Missouri, Columbia). Bender and co-authors followedinsulin resistance in genetically obese rats. After spontaneous and vigorous periodic exercise, Bender et al recorded a normalization of body fat, reduction in glucose, and a decreased insulin resistance.

Shawn B. Bender, Sean C. Newcomer, and M. Harold Laughlin. Differential vulnerability of skeletal muscle feed arteries to dysfunction in insulin resistance: impact of fiber type and daily activity. Am J Physiol Heart Circ Physiol 300: H1434-H1441, 2011.

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