Shedding of the Glycocalyx and Capillary Hemodynamics

We know that the endothelial surface is coated with glycocalyx. But why should we be concerned about the effects of shedding the glycocalyx on microvascular hemodynamics? Editor in Chief William C. Stanley talks with senior author Herbert Lipowsky (Pennsylvania State University) and leading expert Jos A. Spaan (University of Amsterdam) about the unique model presented in the article by Lipowsky et al that mimics aspects of acute vascular inflammation and investigates how shedding of the glycocalyx impacts many pathologies including diabetes.

Herbert H. Lipowsky, Lujia Gao, and Anne Lescanic. Shedding of the Endothelial Glycocalyx in Arterioles, Capillaries and Venules and its Effect on Capillary Hemodynamics During Inflammation. Am J Physiol Heart Circ Physiol, published ahead of print September 16, 2011, doi:10.1152/ajpheart.00803.2011.

00:0000:00

DHEA inhibits the Src/STAT3 constitutive activation

Pulmonary hypertension affects millions of patients with increasing prevalence each year, and clinical treatments are still in their infancy. In our latest podcast, Associate Editor Leon de Windt talks with senior author Sebastien Bonnet (Universite Laval) and leading expert Laura Gonzalez Bosc (University of New Mexico) about the article by Paulin et al, which reports the first demonstration of DHEA blocking two major transcription factors—STAT3 and NFAT. Is DHEA, a commercially available natural steroid hormone and antioxidant, the newest entry point for pharmacological intervention and treatment of pulmonary hypertension? Listen in and find out.

Roxane Paulin, Jolyane Meloche, Maria Helena Jacob, Malik Bisserier, Audrey Courboulin, and Sebastien Bonnet. Dehydroepiandrosterone inhibits the Src/STAT3 constitutive activation in pulmonary arterial hypertension. Am J Physiol Heart Circ Physiol, published ahead of print September 2, 2011, doi:10.1152/ajpheart.00654.2011.

00:0000:00