In pursuit of scientific excellence - sex matters

Sex and gender matter in physiology, but are frequently ignored in scientific publications. In our latest podcast, Editor in Chief William Stanley has a lively conversation with leading experts Virginia Miller (Mayo Clinic) and Jane Reckelhoff (University of Mississippi) about the importance of sex and gender differences in physiology research and publications. Clear sex differences are apparent at the molecular, cellular and whole organ levels, prompting a new editorial policy for the American Physiological Society publications which requires reporting of the sex and/or gender of animals and humans, as well as all derived materials. Learn about how to approach this important issue in your work, and the surprising effects of sex on physiology from the molecular level on up.

Virginia M. Miller. In pursuit of scientific excellence - sex matters Am J Physiol Heart Circ Physiol, published ahead of print February 10, 2012, doi: 10.1152/ajpheart.00073.2012.

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Fructose diet-induced cardiomyocyte Ca2+ cycling abnormality

In our latest podcast we explore the cardiac-specific effects of a high fructose diet. An inventive new study by Mellor et al investigates excitation contraction coupling changes in myocytes isolated from an experimental mouse model. These studies reveal, upon high fructose feeding, marked alterations in myocyte Ca2+ handling, but with maintained contractile function. Associate Editor Meredith Bond and leading expert Susan Howlett (Dalhousie University) interview senior author Lea Delbridge (University of Melbourne) about her exciting new work on diabetic cardiomyopathy.

Kimberley M Mellor, Igor R Wendt, Rebecca H Ritchie, and Lea M.D. Delbridge. Fructose diet treatment in mice induces fundamental disturbance of cardiomyocyte Ca2+ handling and myofilament responsiveness Am J Physiol Heart Circ Physiol, published ahead of print December 23, 2011, doi:10.1152/ajpheart.00797.2011.

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Molecular mechanisms linking salt to hypertension

It is well known that there is no single cause of hypertension, but many of the factors that contribute to hypertension are known. Our latest podcast spotlights an elegant new Review article by Blaustein and colleagues which focuses on the interplay of salt and the secretion and action of endogenous ouabain. Associate Editor Irving Zucker interviews senior author, and fellow Associate Editor, Mordecai Blaustein (University of Maryland), along with leading expert John Osborn (University of Minnesota) about how endogenous ouabain might contribute to salt-sensitive hypertension and plays a central role in the alterations in the central nervous system, kidney and vasculature which contribute to chronic hypertension.

Mordecai P. Blaustein, Frans HH Leenen, Ling Chen, Vera A. Golovina, John M Hamlyn, Thomas L Pallone, James W. Van Huysse, Jin Zhang, Withrow Gil Wier. How NaCl raises blood pressure: A new paradigm for the pathogenesis of salt-dependent hypertension Am J Physiol Heart Circ Physiol, published ahead of print November 4, 2011, doi:10.1152/ajpheart.00899.2011.

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BH4 and Vascular Function in Women

What's the problem with arterial function following menopause? Listen as Editor in Chief William Stanley, senior author Kerrie Moreau (University of Colorado Denver), and leading women’s health expert Virginia Miller (Mayo Clinic) engage in a lively conversation about the latest clinical study by Moreau et al on the role of estrogen and uncoupled nitric oxide synthase in arterial stiffening in post-menopausal women. Can early intervention with estrogen combat accelerated vascular aging after menopause?

Kerrie L Moreau, Amie Meditz, Kevin Deane, Wendy M. Kohrt. Tetrahydrobiopterin Improves Endothelial Function and Decreases Arterial Stiffness in Estrogen-Deficient Postmenopausal Women Am J Physiol Heart Circ Physiol, published ahead of print January 13, 2012, doi:10.1152/ajpheart.01065.2011.

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