O-GlcNAc Signaling During Hypertrophy

Does protein glycosylation drive cardiac hypertrophy? In our latest podcast, Editor in Chief William Stanley talks with senior author Steven P. Jones (University of Louisville) and leading expert John Chatham (University of Alabama at Birmingham) to discuss the work by Facundo et al that explores the role of O-GlcNAc in pathological cardiac hypertrophy through NFAT modification. Listen as they discuss the complexities and importance of O-GlcNAc signaling, and explore the methodological challenges in assessing protein O-GlcNAcylation. Is there a role in heart failure or diabetic cardiomyopathy? Listen in and find out.

Heberty T. Facundo, Robert E. Brainard, Lewis J Watson, Gladys A. Ngoh, Tariq Hamid, Sumanth D. Prabhu, and Steven P. Jones O-GlcNAc Signaling is Essential for NFAT-Mediated Transcriptional Reprogramming During Cardiomyocyte Hypertrophy Am J Physiol Heart Circ Physiol, published ahead of print March 9, 2012, doi: 10.1152/ajpheart.00775.2011.

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Mitochondrial Adaptations and Myocardial Energetics

The protective effect of ischemic preconditioning lasts for only a few hours, then reappears about a day later in what is termed the Second Window of Protection (SWOP). In this podcast Editor in Chief William Stanley interviews senior author Edward McFalls (VA Medical Center, University of Minnesota) and leading expert Nazareno Paolocci (Johns Hopkins University) about the work by Cabrera et al, which brings together an elegant animal model, cutting-edge proteomics technology, and clinical cardiologist and cardiovascular physiologist to uncover the role of the mitochondria and energetics in mediating SWOP.

Jesus A Cabrera, Elizabeth A Ziemba, Robert Colbert, Lorraine Anderson, Willem Sluiter, Dirk J. Duncker, Tammy A Butterick, Joseph Sikora, Herbert B Ward, Rosemary F Kelly, and Edward O McFalls. Altered Expression of Mitochondrial Electron Transport Proteins and Improved Myocardial Energetic State During Late Ischemic Preconditioning Am J Physiol Heart Circ Physiol, published ahead of print March 2, 2012, doi: 10.1152/ajpheart.00372.2011.

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Photoplethysmography with Valsalva Maneuver Reflects Filling Pressure

What do Valsalva, the 17th century Italian physician, and smartphones have in common? Listen to our latest intriguing podcast which explores how the Valsalva Maneuver, when paired with finger photoplethysmography using a simple pulse oximetry probe, may provide cardiologists with an alternative to cardiac catheterization for heart failure patients. Associate Editor Ajay Shah interviews lead author Harry Silber (Johns Hopkins University) and expert Charles Chung (University of Arizona) about the work by Silber and colleagues, which knits together classical cardiovascular physiology, clinical cardiology, and inventive uses of existing technologies to provide insights into the left ventricular filling pressure of heart failure patients.

Harry A. Silber, Jeffrey C. Trost, Peter V. Johnston, W. Lowell Maughan, Nae-Yuh Wang, Edward K. Kasper, Thomas R. Aversano, and David E. Bush. Finger Photoplethysmography During the Valsalva Maneuver Reflects Left Ventricular Filling Pressure Am J Physiol Heart Circ Physiol, published ahead of print March 2, 2012, doi: 10.1152/ajpheart.00609.2011.

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Hemin toxicity and autophagy

We know that hemin toxicity effects vascular endothelial cells, which may contribute to cardiovascular diseases. But what is the underlying molecular mechanism? In our newest podcast, Associate Editor Christine des Rosiers interviews senior author Victor Darley-Usmar (University of Alabama at Birmingham) and leading expert Neil Hogg (Medical College of Wisconsin) about the connections between lipid peroxidation in cells and its damaging effects on mitochondrial function, and the role autophagy may play in protecting those mitochondria from damage.

Ashlee N. Higdon, Gloria A. Benavides, Balu K. Chacko, Xiaosen Ouyang, Michelle S. Johnson, Aimee Landar, Jianhua Zhang, Victor M. Darley-Usmar. Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: the protective role of autophagy Am J Physiol Heart Circ Physiol, published online April 1, 2012, doi: 10.1152/ajpheart.00584.2011.

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