Cell-Based Therapy for Prevention and Reversal of Myocardial Remodeling

Where are the prospects for cell-based therapies for myocardial infarction and heart failure? Listen as Editor in Chief William C. Stanley discusses stem cell therapies for heart disease and the new Review article by Karantalis et al with senior author Joshua Hare (University of Miami) and leading expert Jianyi (Jay) Zhang (University of Minnesota). This paper thoroughly examines cell-based therapies for treatment of acute myocardial infarction and chronic ischemic cardiomyopathy. What are the prospects for moving cell therapies out of the lab and into routine clinical practice?

Vasileios Karantalis, Wayne Balkan, Ivonne Hernandez Schulman, Konstantinos Hatzistergos, and Joshua M. Hare Cell-Based Therapy for Prevention and Reversal of Myocardial Remodeling Am J Physiol Heart Circ Physiol, published online May 25, 2012, doi: 10.1152/ajpheart.00221.2012.

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Physiological Aspects of Cardiac Tissue Engineering

How do you grow cardiac muscle in a dish? Listen as myocardial tissue engineering pioneer Thomas Eschenhagen (University Medical Center Hamburg Eppendorf) talks with Associate Editor Leon de Windt and leading expert Pieter Doevendans (University of Utrecht Medical Centre) about the evolution of cardiac tissue engineering. From humble beginnings in chick embryonic cardiomyocytes to current state-of-the-art techniques with human tissue, we explore the development of engineered myocardium for drug screening and clinical applications.

Thomas Eschenhagen, Alexandra Eder, Ingra Vollert, and Arne Hansen Physiological Aspects of Cardiac Tissue Engineering Am J Physiol Heart Circ Physiol, published online May 11, 2012, doi: 10.1152/ajpheart.00007.2012.

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