MMPs: Milestones, Myths, and (Mis)Perceptions

So you thought that the role of matrix metalloproteinases (MMPs) in myocardial remodeling had been all worked out? Well, it's not so simple. The latest Review article by Iyer et al debunks myths and demystifies perceptions surrounding MMPs and their role in regulating the extracellular matrix and cardiac structure. In our new podcast, Editor in Chief William Stanley interviews lead author Merry Lindsey (University of Texas Health Science Center San Antonio) and expert Loren Wold (The Research Institute at Nationwide Children's Hospital) about the work by Lindsey and others in the MMP/TIMP field. Listen now to discover more.

Rugmani Padmanabhan Iyer, Nicolle L. Patterson, Gregg B. Fields, and Merry L. Lindsey The history of matrix metalloproteinases: milestones, myths, and misperceptions Am J Physiol Heart Circ Physiol, published online August 17, 2012, doi: 10.1152/ajpheart.00577.2012.

00:0000:00

Right Ventricular Arrhythmogenic Remodeling in Heart Failure

Can translational research using donated human hearts uncover the mechanism behind cardiac sudden death in heart failure patients? In our latest podcast, Editor in Chief William Stanley interviews renowned researcher Igor Efimov (Washington University) and global expert Kenneth Laurita (Case Western Reserve University) about the latest work by Lou et al. demonstrating enhanced dispersion of repolarization in right ventricles obtained from heart failure patients.

Qing Lou, Deborah L Janks, Katherine Holzem, Di Lang, Birce Onal, Christina M Ambrosi, Vadim V Fedorov, I-Wen Wang, and Igor R. Efimov Right Ventricular Arrhythmogenesis in Failing Human Heart: The Role of Conduction and Repolarization Remodeling Am J Physiol Heart Circ Physiol, published online October 5, 2012, doi: 10.1152/ajpheart.00457.2012.

00:0000:00