So you thought that the role of matrix metalloproteinases (MMPs) in myocardial remodeling had been all worked out? Well, it's not so simple. The latest Review article by Iyer et al debunks myths and demystifies perceptions surrounding MMPs and their role in regulating the extracellular matrix and cardiac structure. In our new podcast, Editor in Chief William Stanley interviews lead author Merry Lindsey (University of Texas Health Science Center San Antonio) and expert Loren Wold (The Research Institute at Nationwide Children's Hospital) about the work by Lindsey and others in the MMP/TIMP field. Listen now to discover more.
Rugmani Padmanabhan Iyer, Nicolle L. Patterson, Gregg B. Fields, and Merry L. Lindsey The history of matrix metalloproteinases: milestones, myths, and misperceptions Am J Physiol Heart Circ Physiol, published online August 17, 2012, doi: 10.1152/ajpheart.00577.2012.