Sex Differences and Vascular Reactivity to Mental Stress

Do men and women handle mental stress differently? What role do sex differences play in the transduction of muscle sympathetic nerve activity (MSNA) into vascular tone during stress? Associate Editor Irving Zucker explores the recent work by Yang et al in our new podcast interview with lead author Jason Carter (Michigan Technological University) and expert Nisha Charkoudian (U.S. Army Research Institute of Environmental Medicine) in a stimulating conversation germane to the wave of research on sex differences in cardiovascular science. Listen now.

Huan Yang, Thomas Drummer, and Jason R. Carter Sex differences in sympathetic neural and limb vascular reactivity to mental stress in humans Am J Physiol Heart Circ Physiol, published online November 30, 2012, doi: 10.1152/ajpheart.00688.2012.

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Endothelin-1 and Exercise

How can we tame the sleeping giant of excess skeletal muscle blood flow during exercise? In our latest podcast we expand our understanding of the role endothelin-1 plays in regulating skeletal muscle blood flow during whole body, as well as targeted, exercise in healthy patients. Consulting Editor David Gutterman leads this interesting conversation with author Walter Wray (University of Utah) and expert Kevin Dellsperger (University of Missouri-Columbia) about the recent work by Barrett-O’Keefe et al. What are the possibilities for targeting the endothelin-1 pathway in disease states? Listen now.

Zachary Barrett-O'Keefe, Stephen J. Ives, Joel Douglas Trinity, Richard Garrett Morgan, Matthew Jordan Rossman, Anthony J. Donato, Sean Runnels, David E. Morgan, Benjamin S. Gmelch, Amber D. Bledsoe, Russell S. Richardson, and D. Walter Wray Taming the "Sleeping Giant": The Role of Endothelin-1 in the Regulation of Skeletal Muscle Blood Flow and Arterial Blood Pressure during Exercise Am J Physiol Heart Circ Physiol, published online October 26, 2012, doi:10.1152/ajpheart.00603.2012.

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