Liposomal Erythropoietin Protects the Heart

Reducing infarct size to prevent ischemic heart failure in patients with acute myocardial infarction is a known challenge for clinical cardiologists, and few drugs meet this challenge. In our new podcast Associate Editor Masafumi Kitakaze interviews lead author Shinya Minatoguchi (Gifu University Graduate School of Medicine, Gifu, Japan) and expert Tetsuji Miura (Sapporo Medical University School of Medicine, Sapporo, Japan) about the innovative new work by Yamada et al which used liposomal erythropoietin therapy to reduce infarct size in a rabbit heart model. Can this relatively non-invasive drug delivery method become an effective way to reduce infarct size in acute MI human patients? Listen now.

Yoshihisa Yamada, Hiroyuki Kobayashi, Masamitsu Iwasa, Shohei Sumi, Hiroaki Ushikoshi, Takuma Aoyama,
Kazuhiko Nishigaki, Genzou Takemura, Takako Fujiwara, Hisayoshi Fujiwara, Makoto Kiso, and Shinya Minatoguchi
Postinfarct active cardiac-targeted delivery of erythropoietin by liposomes with sialyl Lewis X repairs infarcted myocardium in rabbits Am J Physiol Heart Circ Physiol, published online February 15, 2013, doi: 10.1152/ajpheart.00707.2012.

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JAPANESE VERSION: Liposomal Erythropoietin Protects the Heart

NEW! In this JAPANESE language podcast, Associate Editor Masafumi Kitakaze interviews lead author Shinya Minatoguchi (Gifu University Graduate School of Medicine, Gifu, Japan) and expert Tetsuji Miura (Sapporo Medical University School of Medicine, Sapporo, Japan) about the innovative new work by Yamada et al which used liposomal erythropoietin therapy to reduce infarct size in a rabbit heart model. Can this relatively non-invasive drug delivery method become an effective way to reduce infarct size in acute MI human patients? Listen now.

Yoshihisa Yamada, Hiroyuki Kobayashi, Masamitsu Iwasa, Shohei Sumi, Hiroaki Ushikoshi, Takuma Aoyama,
Kazuhiko Nishigaki, Genzou Takemura, Takako Fujiwara, Hisayoshi Fujiwara, Makoto Kiso, and Shinya Minatoguchi
Postinfarct active cardiac-targeted delivery of erythropoietin by liposomes with sialyl Lewis X repairs infarcted myocardium in rabbits Am J Physiol Heart Circ Physiol, published online February 15, 2013, doi: 10.1152/ajpheart.00707.2012.

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DPP-IV Inhibitor Improves Survival in Murine Heart Failure

Can diabetes treatments also protect the heart? In our latest podcast we explore the work by Takahashi et al, which examined what a DPP-IV inhibitors will do at the level of the heart. Associate Editor Gary Lopaschuk interviews lead author Masanori Asakura (National Cerebral and Cardiovascular Center, Osaka, Japan) and expert Zam Kassiri (University of Alberta) about this exciting new work which pulls together aspects of metabolism, heart failure, anti-diabetic agents and cardioprotection. Listen and learn more.

Ayako Takahashi, Masanori Asakura, Shin Ito, Kyung-Duk Min, Kazuhiro Shindo, Yi Yan, Yulin Liao, Satoru Yamazaki, Shoji Sanada, Yoshihiro Asano, Hatsue Ishibashi-Ueda, Seiji Takashima, Tetsuo Minamino, Hiroshi Asanuma, Naoki Mochizuki, and Masafumi Kitakaze Dipeptidyl-Peptidase IV Inhibition Improves Pathophysiology of Heart Failure and Increases Survival Rate in Pressure-Overloaded Mice Am J Physiol Heart Circ Physiol, published online March 15, 2013, doi: 10.1152/ajpheart.00454.2012.

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