Are "leaking" ryanodine receptor channels during diastole really important in cardiac hypertrophy and heart failure, or are the problems actually related to ryanodine receptors that stay open too long during systole? In this podcast Associate Editor W. Gil Wier interviews lead author Gerhard Meissner (University of North Carolina at Chapel Hill) and leading expert Peter Mohler (Ohio State University) about Meissner's groundbreaking new work by Yamaguchi et al, giving us key insights into this fascinating study. Will we find out exactly which amino acid is involved in calmodulin inhibition of ryanodine receptors? Listen and learn.
Naohiro Yamaguchi, Asima Chakraborty, Tai-Qin Huang, Le Xu, Angela C. Gomez, Daniel A. Pasek, and Gerhard Meissner Cardiac hypertrophy associated with impaired regulation of cardiac ryanodine receptor by calmodulin and S100A1 Am J Physiol Heart Circ Physiol, published online May 10, 2013, doi: 10.1152/ajpheart.00144.2013.