Regulation of Cardiac Ryanodine Receptor by Calmodulin and S100A1

Are "leaking" ryanodine receptor channels during diastole really important in cardiac hypertrophy and heart failure, or are the problems actually related to ryanodine receptors that stay open too long during systole? In this podcast Associate Editor W. Gil Wier interviews lead author Gerhard Meissner (University of North Carolina at Chapel Hill) and leading expert Peter Mohler (Ohio State University) about Meissner's groundbreaking new work by Yamaguchi et al, giving us key insights into this fascinating study. Will we find out exactly which amino acid is involved in calmodulin inhibition of ryanodine receptors? Listen and learn.

Naohiro Yamaguchi, Asima Chakraborty, Tai-Qin Huang, Le Xu, Angela C. Gomez, Daniel A. Pasek, and Gerhard Meissner Cardiac hypertrophy associated with impaired regulation of cardiac ryanodine receptor by calmodulin and S100A1 Am J Physiol Heart Circ Physiol, published online May 10, 2013, doi: 10.1152/ajpheart.00144.2013.

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Low Carbohydrate - High Fat Diet Lowers Blood Pressure in Spontaneously Hypertensive Rats

Can hypertension be treated by substituting fat for carbohydrate in the diet? The recent work by Bosse et al found that a high fat/low carbohydrate diet improved vascular function and reduced blood pressure in hypertensive rats. Listen as Editor in Chief William C. Stanley, lead author Thunder Jalili (University of Utah) and expert Jun Ren (University of Wyoming) discuss the role of dietary fats and carbohydrates in cardiovascular function in hypertension.

John D. Bosse, Han Yi Lin, Crystal Sloan, Quan-Jiang Zhang, E. Dale Abel, Troy J. Pereira, Vernon W. Dolinsky, J. David Symons, and Thunder Jalili A low-carbohydrate/high-fat diet reduces blood pressure in spontaneously hypertensive rats without deleterious changes in insulin resistance Am J Physiol Heart Circ Physiol, published online April 19, 2013, doi: 10.1152/ajpheart.00631.2012.

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Signaling of Immediate Exercise Hyperemia

What do 21st century cardiovascular physiology and classical physiologists in 1920s Cairo, Egypt have in common? Our latest podcast explores the clinical study by Crecelius et al, which seeks to understand the signaling mechanisms involved in blood flow regulation in humans. With a nod to history, Associate Editor Ajay Shah, lead author Frank Dinenno (Colorado State University), and expert Michael Joyner (Mayo Clinic) try to unravel the mysteries of exercise hyperemia. Listen now.

Anne R. Crecelius, Brett S. Kirby, Gary J Luckasen, Dennis G Larson, and Frank A. Dinenno Mechanisms of rapid vasodilation following a brief contraction in human skeletal muscle Am J Physiol Heart Circ Physiol, published online May 3, 2013, doi: 10.1152/ajpheart.00298.2013.

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