Smoking and Sympathetic Nerve Activity in Women

Does increased sympathetic nerve activity put women smokers at greater risk for heart attacks? Yes, according to a new study by Middlekauff and colleagues published recently in AJP-Heart and Circ. In this podcast Associate Editor Irving Zucker interviews senior author Holly Middlekauff (University of California-Los Angeles) and leading expert Vaughan Macefield (University of Western Sydney) about this insightful work which explores how baroreflex control of sympathetic nerve activity is impaired in women smokers. Listen as we explore how normal sympathetic nerve activity fluctuations associated with menstrual cycle hormonal changes in premenopausal women are altered by smoking, as well as second-hand smoke, and chronic smoke inhalation.

Holly R. Middlekauff, Jeanie Park, Harsh Agrawal, Jeffrey A. Gornbein Abnormal sympathetic nerve activity in women exposed to cigarette smoke: a potential mechanism to explain increased cardiac risk Am J Physiol Heart Circ Physiol, published November 15, 2013, doi: 10.1152/ajpheart.00502.2013.

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Human Aspirate - Native Coronary Arteries Versus Vein Grafts

Just two weeks after this podcast was originally recorded, our Editor in Chief Dr. William C. Stanley passed away unexpectedly. We are all tremendously saddened by this loss, but feel that presenting this podcast—the last one recorded with Dr. Stanley—honors his work in the journal, in particular his innovative podcast series. In this podcast Dr. Stanley interviewed author Petra Kleinbongard (University of Essen Medical School) and leading expert William Chilian (Northeast Ohio Medical University) about the work by Kleinbongard and colleagues comparing downstream human coronary aspirate and soluble substances after stent procedures in patients with native coronary arteries and those who had previously undergone revascularization with a saphenous vein graft. Is the potential for microvascular obstruction the same for both sets of patients? Listen as the experts weigh in on this elegant study which examines the pathophysiological consequences of stenting.

Petra Kleinbongard, Theodor Baars, Stefan Moehlenkamp, Philipp Kahlert, Raimund Erbel, Gerd Heusch Aspirate from human stented native coronary arteries vs. saphenous vein grafts: more endothelin but less particulate debris Am J Physiol Heart Circ Physiol, published online October 15, 2013, DOI: 10.1152/ajpheart.00358.2013.

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