Adverse Perinatal Environment Contributes to Altered Cardiac Development and Function

Why are in utero conditions so critical to cardiovascular health after birth? Listen as Associate Editor Ronglih Liao interviews lead author Loren Wold (Ohio State University) and expert Anne Knowlton (University of California, Davis) about the latest insightful work by Velten et al, which tests a “two-hit” hypothesis mouse model—inflammation followed by hyperoxia—to analyze how cardiac function is altered very early in life. Is Wold’s innovative work bringing the 18th century biologist Lamarck’s theory of inheritance of acquired characteristics front and center in 21st century cardiovascular physiology? Listen and find out.


Markus Velten, Matthew W. Gorr, Dane J. Youtz, Christina Velten, Lynette K. Rogers, Loren E Wold Adverse Perinatal Environment Contributes to Altered Cardiac Development and Function Am J Physiol Heart Circ Physiol, published online March 7, 2014. DOI: 10.1152/ajpheart.00056.2014.

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AMPK and Peripheral Vascular Insufficiency

Is AMP kinase activation a potential therapy for patients with peripheral artery disease? Listen as Editor in Chief Irving Zucker interviews lead author Todd Kinsella (Rigel Pharmaceuticals, Inc.) and expert Michael Massett (Texas A & M University) about the interesting new work by Baltgalvis et al. In the quest to improve exercise intolerance that plagues the millions of patients suffering from peripheral artery disease, Kinsella and colleagues developed and tested a series of indirect AMPK activators for beneficial exercise adaptation in a mouse model of aging, inactivity, and obesity. Did Kinsella and colleagues find any effect of AMPK activators on the microvascular and muscle dysfunction associated with intermittent claudication? Listen and find out.


Kristen A. Baltgalvis, Kathy White, Wei Li, Mark D. Claypool, Wayne Lang, Raniel Alcantara, Baljit K. Singh, Annabelle M. Friera, John McLaughlin, Derek Hansen, Kelly McCaughey, Henry Nguyen, Ira J. Smith, Guillermo Godinez, Simon J. Shaw, Dane Goff, Rajinder Singh, Vadim Markovtsov, Tian-Qiang Sun, Yonchu Jenkins, Gerald Uy, Yingwu Li, Alison Pan, Tarikere Gururaja, David Lau, Gary Park, Yasumichi Hitoshi, Donald G. Payan, Todd M. Kinsella Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice Am J Physiol Heart Circ Physiol, published online February 21, 2014. DOI: 10.1152/ajpheart.00839.2013.

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