Deformation Causes Vascular Alignment During Angiogenesis

What does “changing the boundary conditions” mean? In our latest author interview, Deputy Editor Dr. Merry Lindsey asks lead author Dr. Jeffrey Weiss (University of Utah) this very question about his innovative new work exploring the relationship between tissue mechanics and angiogenesis. Expert Hai-Chao Han (University of Texas at San Antonio) lends his insight into the importance of studying the mechanics of blood vessel formation. Will the work by Underwood et al, which elegantly blends computational and biological approaches, someday lead to new experimental applications, such as pre-aligned microvasculatures for engineered tissue constructs? Listen and learn.


Clayton J. Underwood, Lowell T. Edgar, James B. Hoying, Jeffrey A. Weiss Cell-generated traction forces and the resulting matrix deformation modulate microvascular alignment and growth during angiogenesis Am J Physiol Heart Circ Physiol, published July 15, 2014. DOI: 10.1152/ajpheart.00995.2013.

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Wave Potential and the One-Dimensional Windkessel

While wave separation analysis is considered the gold standard for assessing pressure and flow waves in the arterial system, how do we account for self-cancelling flow waves during diastole? In this podcast Associate Editor Dr. Masafumi Kitakaze interviews lead author Jonathan Mynard (Murdoch Children’s Research Institute, Australia) and expert Berend Westerhof (Edwards Lifesciences BMEYE, Netherlands) about the innovative work by Mynard and co-author Joseph Smolich, which used mathematical models and experimental studies in sheep to discover the novel concepts of wave potential and the one-dimensional windkessel. With attention now being paid to the origin and behavior of self-cancelling diastolic waves, we may be poised to better understand the relationship between pressure and flow in cardiovascular health and disease states. Listen now and learn more.

Jonathan P Mynard , Joseph J. Smolich Wave potential and the one-dimensional windkessel as a wave-based paradigm of diastolic arterial hemodynamics Am J Physiol Heart Circ Physiol, published May 30, 2014. DOI: 10.1152/ajpheart.00293.2014.

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Aromatase Modulates Cardiac Ischemic Stress Response

Beyond vascular effects, can estrogen produced in the heart have an influence on cardiac function? Is the local action of aromatase conversion of testosterone to estrogen important for the stressed heart? Listen as Guest Editor Dr. Virginia Miller interviews lead author Lea Delbridge (University of Melbourne) and expert Fred Naftolin (New York University) about the exciting new work by Bell et al showing aromatase expression in the heart at both the messenger and protein level. Given that the human heart is sexually dimorphic, and that this may extend past development to actual function, what insightful differences did the authors find in male and female aromatase transgenic mouse hearts? Listen now.


James R. Bell, Gabriel B. Bernasochi, Upasna Varma, Wah Chin Boon, Stuart J. Ellem, Gail P. Risbridger, Lea M. D. Delbridge Aromatase transgenic upregulation modulates basal cardiac performance and the response to ischemic stress in male mice Am J Physiol Heart Circ Physiol, published May 1, 2014. DOI: 10.1152/ajpheart.00012.2014.

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Aortic Valve Sclerosis in Mice Deficient in Endothelial Nitric Oxide Synthase

What is the sequence of events in the formation of fibrosis and calcification in aortic valves, and what role does endothelium-derived nitric oxide play in these pathways? Listen as Associate Editor Ajay Shah interviews lead author Robert Weiss (University of Iowa) and expert Jane Leopold (Brigham and Women's Hospital) about the innovative and novel work by El Accaoui et al. With a unique combination of in vitro co-culture and in vivo knockout mouse studies, Weiss and colleagues seek to shed light on a clinically-relevant and increasingly important question: when does aortic sclerosis begin and how can it be treated before aortic stenosis develops?


Ramzi N. El Accaoui, Sarah T. Gould, Georges P. Hajj, Yi Chu, Melissa K. Davis, Diane C. Kraft, Donald D. Lund, Robert M. Brooks, Hardik Doshi, Kathy A. Zimmerman, William Kutschke, Kristi S. Anseth, Donald D. Heistad, Robert M. Weiss Aortic valve sclerosis in mice deficient in endothelial nitric oxide synthase Am J Physiol Heart Circ Physiol, published May 1, 2014. DOI: 10.1152/ajpheart.00392.2013.

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