Angiogenic Response to Exercise and Resveratrol

Can the polyphenol antioxidant resveratrol, commonly found in red wine, augment the angiogenic effects of exercise training? Guest Editor Nisha Charkoudian (U.S. Army Research Institute of Environmental Medicine) interviews lead author Lasse Gliemann (University of Copenhagen) and expert Michael Joyner (Mayo Clinic) about the fascinating, and somewhat surprising, work by Gliemann and colleagues combining exercise training in older men with resveratrol supplementation in pill form. With so much media hype focused on the possibility of a so-called "exercise pill," we break down the myths and focus on the facts in this engaging podcast. Brush off your bicycle helmet, and listen now.


Lasse Gliemann, Jesper Olesen, Rasmus Sjørup Biensø, Jakob Friis Schmidt, Thorbjorn Akerstrom, Michael Nyberg, Anna Lindqvist, Jens Bangsbo, Ylva Hellsten Resveratrol modulates the angiogenic response to exercise training in skeletal muscles of aged men Am J Physiol Heart Circ Physiol, published October 15, 2014. DOI: 10.1152/ajpheart.00168.2014.

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Dantrolene suppresses Ca2+ sparks and Ca2+ waves

In this podcast we highlight the recent study by Domeier and colleagues, which looked for a way to pharmacologically restore proper function of the ryanodine receptor with advancing age. Did they find it? Editor in Chief Dr. Irving Zucker interviews lead author Timothy Domeier (The University of Missouri School of Medicine) and expert Eric Sobie (Mount Sinai School of Medicine) about this fascinating study investigating whether ryanodine receptor mediated calcium release in the aged heart was altered by dantrolene. In fact, Domeier and colleagues did find that dantrolene provided a protective effect against pro-arrhythmic calcium sparks and calcium waves in diastole. Hear about this finding and much more by clicking play below.


Timothy L. Domeier, Cale J. Roberts, Anne K. Gibson, Laurin M. Hanft, Kerry S. McDonald, Steven S. Segal Dantrolene suppresses spontaneous Ca2+ release without altering excitation-contraction coupling in cardiomyocytes of aged mice Am J Physiol Heart Circ Physiol, published September 15, 2014. DOI: 10.1152/ajpheart.00287.2014.

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Noninvasive Longitudinal Measurements of [Ca2+] in Arterioles of Hypertensive Optical Biosensor Mice

Have noninvasive calcium signaling measurement methods turned a new corner? Yes, according to a unique new study by Mauban et al. Associate Editor Nancy Kanagy interviews senior author W. Gil Wier (University of Maryland School of Medicine) and leading expert Mark Nelson (University of Vermont) about the work by Wier and colleagues, which measured intracellular levels of calcium noninvasively in the same animal over a period of several weeks. How? Wier and co-authors ingeniously immobilized the mouse ear, enabling the use of a FRET-based ratiometric calculation of actual intracellular calcium levels in vascular cells inside the living animal. Does this innovative methodology launch new possibilities for evaluating calcium signaling changes during disease development? Listen and find out.


Joseph R. H. Mauban, Seth T. Fairfax, Mark A. Rizzo, Jin Zhang, Withrow Gil Wier A method for noninvasive longitudinal measurements of [Ca2+] in arterioles of hypertensive optical biosensor mice Am J Physiol Heart Circ Physiol, published July 15, 2014. DOI: 10.1152/ajpheart.00182.2014.

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