Pressure-Induced Endothelial Dysfunction

Is upregulation of local generation of angiotensin II in arteries causing the loss of endothelium-dependent dilation in response to short-term increases in blood pressure? Associate Editor Nancy Kanagy (University of New Mexico) interviews lead author Nicholas Flavahan (Johns Hopkins University) and content expert Gregory Fink (Michigan State University) about the insightful work by Flavahan and colleagues that seeks to disentangle the complicated cause-and-effect relationship between the renin-angiotensin system and high blood pressure. So what’s the bottom line? Are acute, however brief, increases in blood pressure bad for our arteries? Listen and learn.


Yingzi Zhao, Sheila Flavahan, Susan W. Leung, Aimin Xu, Paul M. Vanhoutte, Nicholas A. Flavahan Elevated pressure causes endothelial dysfunction in mouse carotid arteries by increasing local angiotensin signaling Am J Physiol Heart Circ Physiol, published February 15, 2015. DOI: 10.1152/ajpheart.00775.2014.

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Aging, Endothelial Dysfunction and SIRT1 Activation

We all know that aging is associated with a loss in vascular endothelial function, but what role does the SIRT1 system play in aiding aging-related processes, such as increased superoxide production and oxidant stress? In this podcast Consulting Editor Michael Wolin interviews lead author Lindsey Gano (University of Colorado, Denver) and content expert Zvonimir Katusic (Mayo Clinic) about the work by Gano et al which used the SIRT1 activator SRT1720 in aging mice to study the effects on endothelium-dependent dilation through COX-2 mediated dilation. Did the authors find a reduction in oxidative stress and inflammation? Listen and learn.


Lindsey B. Gano, Anthony John Donato, Hamza M. Pasha, Christopher M. Hearon Jr., Amy L. Sindler, Douglas R. Seals The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice  Am J Physiol Heart Circ Physiol, published December 15, 2014. DOI: 10.1152/ajpheart.00377.2014.

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