Angiotensin II and Reflex Vasoconstriction with Age

What are the key age-related differences in the reflex vasoconstrictor response in skin microvessels, and how are angiotensin II and Rho-kinase activation involved? These questions and more are answered in our latest podcast on the work by Lang and Kolb. Listen as Associate Editor Debra Diz (Wake Forest University School of Medicine) interviews lead author James Lang (Des Moines University) and content expert Caitlin Thompson-Torgerson (Anne Arundel Community College) about this intriguing work which has clear thermoregulatory ramifications for older adults. Is there a potential upstream role for reactive oxygen species in upregulating Angiotensin II? How can the primary effects of aging in a healthy older adult cohort be extrapolated to disease states such as diabetes? Listen to find out.


James A. Lang , Kelsey E. Kolb Angiotensin II type I receptor blockade attenuates reflex cutaneous vasoconstriction in aged but not young skin Am J Physiol Heart Circ Physiol, published May 15, 2015, DOI: 10.1152/ajpheart.00017.2015.

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Environmentally Persistent Free Radicals Increase Post Ischemic Dysfunction

What is the role of environmentally persistent free radicals (EPFRs) in increasing cardiac vulnerability to subsequent myocardial infarction ischemia/reperfusion injury? Guest Editor Loren Wold (The Ohio State University) interviews lead author Kurt Varner (Louisiana State University Health Sciences Center New Orleans) and content expert Kevin Lord (University of the Incarnate Word) in this lively and engaging podcast which explores the work by Burn et al. Using a nose-only inhalation technique, Burn and Varner sought to mimic “real world” air pollution exposure to EPRFs and reduce any potential inflammation response from intratracheal installation of particulate matter. Which components of particulate matter contribute most to oxidative stress? How does the work by Burn and Varner fit into next-generation tobacco products, such as e-cigarettes? Listen to find out.


Brendan R. Burn , Kurt J. Varner Environmentally persistent free radicals compromise left ventricular function during ischemia/reperfusion injury Am J Physiol Heart Circ Physiol, published May 1, 2015, DOI: 10.1152/ajpheart.00891.2014.

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