Determinants of Intra-cardiac Kinetic Energy

What do we know about the kinetic energy of intra-cardiac blood flow during the two phases of the cardiac cycle? Virtually nothing. That’s what Steding-Ehrenborg et al seek to change in a new study we explore in this podcast. Listen as Associate Editor Fabio Recchia (Temple University Lewis Katz School of Medicine, and Scuola Superiore Sant'Anna, Pisa, Italy) interviews lead author Katarina Steding-Ehrenborg (Lund University) and content expert Martin Ugander (Karolinska University Hospital) about how the authors used state-of-the-art cardiac magnetic resonance imaging with 4-dimensional phase-contrast sequences to compare kinetic energy in atrial and ventricular chambers in both healthy volunteers and elite endurance athletes. What are the differences in the filling mechanisms between the two chambers of the heart, and how does this affect cardiac pump function? What does high, or low, intra-cardiac blood flow kinetic energy really mean? Listen as we unpack the details of this intriguing, ground-breaking new work.

Katarina Steding-Ehrenborg, Per Martin Arvidsson, Johannes Toger, Mattias Rydberg, Einar Heiberg, Marcus Carlsson, Hakan Arheden Determinants of kinetic energy of blood flow in the four-chambered heart in athletes and sedentary controls Am J Physiol Heart Circ Physiol, published January 1, 2016. DOI: 10.1152/ajpheart.00544.2015.


Roles of CSE and MPST in Coronary Vasoregulation

What role does hydrogen sulfide play in coronary vascular function? That’s just what lead author Lakshmi Santhanam and colleagues set out to uncover in the work by Kuo et al, which we discuss in this podcast. Associate Editor Nancy Kanagy (University of New Mexico School of Medicine) interviews Santhanam (Johns Hopkins University) and content expert Christopher Kevil (Louisiana State University) about the role and source of hydrogen sulfide in coronary arteries and the discovery that the endothelial enzyme 3-mercaptypyruvate sulfertransferase (MPST) is the primary regulator. Does MPST operate in other vascular beds? Are the fluorescence indicators used by Santhanam and co-authors a reliable tool to detect real-time measurements of hydrogen sulfide production? Listen and find out.

Maggie M. Kuo, Dae Hee Kim, Sandeep Jandu, Yehudit Bergman, Siqi Tan, Huilei Wang, Deepesh R. Pandey, Theodore P. Abraham, Artin A. Shoukas, Dan E. Berkowitz, Lakshmi Santhanam MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery Am J Physiol Heart Circ Physiol, published January 1, 2016. DOI: 10.1152/ajpheart.00574.2014.