How well do we understand the post-translational molecular mechanisms regulating changes in metabolism in the newborn heart? This podcast seeks the answer, as Associate Editor Ajay Shah (King’s College London, British Heart Foundation Centre of Excellence) interviews lead author Gary Lopaschuk (University of Alberta) and content expert Luc Bertrand (Université catholique de Louvain) about the work by Fukushima et al, which found rapid acetylation of a number of fatty acid oxidative enzymes, and increased fatty acid oxidation activity, in the newborn rabbit heart. Why is increased expression of mitochondrial acetyltransferase GCN5L1 important in the changes observed by Lopaschuk and colleagues? Could this be a “master regulator” of protein acetylation? Listen and find out.
Arata Fukushima, Osama Abo Alrob, Liyan Zhang, Cory S Wagg, Tariq Altamimi, Sonia Rawat, Ivan M. Rebeyka, Paul F. Kantor, Gary D. Lopaschuk Acetylation and Succinylation Contribute to Maturational Alterations in Energy Metabolism in the Newborn Heart Am J Physiol Heart Circ Physiol, published June 3, 2016. DOI: 10.1152/ajpheart.00900.2015