AngII and Aging-Induced Endothelial Dysfunction

Aging, as we all know, is unavoidable and leads to an increased risk for vascular dysfunction and cardiovascular pathologies. So what are the mechanisms responsible for aging-induced vascular dysfunction? That’s just what Flavahan et al set out to investigate in their latest work in AJP-Heart and Circ. Listen as Editor in Chief Dr. Irving H. Zucker (University of Nebraska Medical Center) interviews lead author Nick Flavahan (Johns Hopkins University) and content expert Edward Lakatta (National Institute on Aging, National Institutes of Health) about Flavahan’s work, which builds on previous studies by Lakatta. Chronic in vivo inhibition of angiotensin activity protects endothelial function, but is it due to blockade of the systemic Renin-Agiotensin System (RAS) or the local vascular angiotensin system? What role do changes in anti-oxidant scavenging mechanisms play in endothelial dysfunction associated with aging? How do flow-mediated dilation and changes in angiotensin receptor expression fit into the big picture of aging? Listen and find out.


Sheila Flavahan, Fumin Chang, Nicholas A. Flavahan Local Renin-Angiotensin System Mediates Endothelial Dilator Dysfunction in Aging Arteries Am J Physiol Heart Circ Physiol, published July 15, 2016. DOI: 10.1152/ajpheart.00422.2016

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Sympathetic Reactivity and Family History of Hypertension

How does family history of hypertension contribute to sympathetic neural control of blood pressure, and what role does mental stress play in blood pressure regulation? The latest work by Fonkue et al seeks to answer these very questions. Listen as Consulting Editor Nisha Charkoudian (U.S. Army Research Institute of Environmental Medicine) interviews lead author Jason Carter (Michigan Technological University) and content expert Megan Wenner (University of Delaware) about the study by Carter and colleagues, which used microneurography to measure muscle sympathetic nerve activity (MSNA) during an acute bout of mental stress (performing mental math) in both women and men with, and without, a family history of hypertension. Can evaluations of larger groups over several years help determine if the sympathetic nervous system plays an essential role in the development of hypertension in those with a family history of the disease? Listen and find out.


Ida T. Fonkoue, Min Wang, Jason R. Carter Sympathetic neural reactivity to mental stress in offspring of hypertensive parents: 20 years revisited Am J Physiol Heart Circ Physiol, published July 1, 2016. DOI: 10.1152/ajpheart.00378.2016

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Vascular Health After Preeclampsia

What is the mechanism behind the increased risk for cardiovascular and renal diseases in women who have previously suffered from early-onset preeclampsia? Listen as Associate Editor Robert Hester (University of Mississippi Medical Center) interviews lead author Anne Marijn van der Graaf (University of Groningen Medical Center) and content expert Ira Bernstein (University of Vermont Medical Center) about the clinical study by van der Graaf and colleagues, which compared the arterial stiffness of healthy women with a history of preeclamptic pregnancy to healthy women with no preeclamptic pregnancy history after low sodium and high sodium diets. Were formerly preeclamptic women able to adjust their arterial stiffness after eating a low sodium diet? What is the role of vessel wall function and the glycocalyx as markers of vascular stiffness? Listen and find out.


Anne Marijn van der Graaf, Nina D. Paauw, Tsjitske J. Toering, Martin Feelisch, Marijke M. Faas, Thomas R. Sutton, Magdalena Minnion, Joop D. Lefrandt, Sicco A. Scherjon, Arie Franx, Gerjan Navis, A. Titia Lely Impaired sodium-dependent adaptation of arterial stiffness in formerly preeclamptic women: the RETAP-vascular study Am J Physiol Heart Circ Physiol, published June 1, 2016. DOI: 10.1152/ajpheart.00010.2016

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