Update on Hormone Therapy Trials

Did the publication of the Women’s Health Initiative (WHI) in 2002 lead to assumptions that may prevent menopausal women from being properly treated? Listen to this enlightening conversation as Editor in Chief Dr. Irving H. Zucker (University of Nebraska Medical Center) interviews senior author Virginia M. Miller (Mayo Clinic College of Medicine) and content expert Barbara Alexander (University of Mississippi) about the new review article by Miller and Harman aimed at understanding the controversies surrounding the WHI and menopausal hormone therapy. This engaging podcast provides a primer on the WHI, confronts the dangers of using imprecise terminology (conjugated equine estrogen compared to 17β-estradiol), and shines a light on the still-evolving study of menopausal hormone therapy. Do the limitations of the Women’s Health Initiative still have repercussions for the daily lives of menopausal women some 15 years post-publication? Listen now.


Virginia M. Miller and S. Mitchell Harman An update on hormone therapy in postmenopausal women: mini-review for the basic scientist  Am J Physiol Heart Circ Physiol, published November 1, 2017. DOI: 10.1152/ajpheart.00383.2017


Aging, Exercise, and Endothelial Cell Senescence

Can regular aerobic exercise diminish the damaging effects of aging on the vascular system by improving the health of vascular endothelial cells? In this insightful podcast, Associate Editor Nancy Kanagy interviews lead author Matthew Rossman (University of Colorado Boulder) and content expert Raymond Migrino (Phoenix VA Health Care System) about the work by Rossman et al focusing on age-related changes in endothelial cell senescence and associated changes in endothelial cell function that occurs with normal, healthy aging. Habitual exercise has been shown to reduce age-related phenotypic changes such as increased arterial stiffness and reduced endothelial cell function. Did Rossman and colleagues find that regular aerobic exercise in older adults ameliorated increases in endothelial cell senescence? Listen and learn more.


Matthew J. Rossman, Rachelle E. Kaplon, Sierra D. Hill, Molly N. McNamara, Jessica R. Santos-Parker, Gary L. Pierce, Douglas R. Seals, Anthony J. Donato Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and relation to vascular endothelial function Am J Physiol Heart Circ Physiol, published November 1, 2017. DOI: 10.1152/ajpheart.00416.2017