Endothelial Control of Blood Pressure

Do changes in endothelial function in a high-fat, high-sugar diet model of metabolic syndrome mitigate the effects of elevated sympathetic nervous system activity to increase blood pressure? Listen as Associate Editor Debra Diz (Wake Forest University School of Medicine) interviews first author Sylvain Battault (Avignon University, France) and content expert Julie Y.H. Chan (Chung Gung Memorial Hospital, Taiwan) about the intriguing new work by Battault and co-authors which has potential clinical implications for obesity with, and without, hypertension. Did the authors find that an increase in autonomic sympathetic outflow translates to high blood pressure in their model of metabolic syndrome? Does this study suggest that the endothelium modulates adrenergic-dependent vasoconstriction as a last-chance defense mechanism against metabolic syndrome -associated hypertension? Listen and find out.

 

Sylvain Battault, Cindy Meziat, Alessandro R Nascimento, Laura Braud, Sandrine Gayrard, Christian Legros, Frederic De Nardi, Jocelyne Drai, Olivier Cazorla, Jérôme Thireau, Gregory Meyer, and Cyril Reboul Vascular endothelial function masks increased sympathetic vasopressor activity in rats with metabolic syndrome Am J Physiol Heart Circ Physiol, published November 10, 2017. DOI: doi/10.1152/ajpheart.00217.2017

00:0000:00

NRG-1 Inhibits Macrophage Activation During Tissue Fibrosis

Does neuregulin-1 (NRG-1) directly affect macrophages present during the inflammatory phase of cardiac fibrosis? Listen as Deputy Editor Merry Lindsey (University of Mississippi Medical Center) interviews authors Gilles De Keulenaer and Vincent Segers (both at University of Antwerp, Belgium) and content expert Amy Bradshaw (Medical University of South Carolina) about the novel study by Vermeulen et al. What “accidental discovery” in the lab lead the authors to expand their study of NRG-1 in the fibrosis of the heart to skin and lung? Are the similarities in collagen deposition in the extracellular matrix of the heart, skin, lung and other tissues driven by macrophages? “Paying attention to accidental discoveries can lead to new avenues of research,” said Dr. Merry Lindsey. Did the authors find that the neuregulin-ErbB4 system plays a role in both interstitial and perivascular fibrosis? Listen and find out.

 

Zarha Vermeulen, Anne-Sophie Hervent, Lindsey Dugaucquier, Leni Vandekerckhove, Miche Rombouts, Matthias Beyens, Dorien M. Schrijvers, Guido R. Y. De Meyer, Stuart Maudsley, Gilles W. De Keulenaer*, and Vincent F. M. Segers Inhibitory actions of the NRG-1/ErbB4 pathway in macrophages during tissue fibrosis in the heart, skin, and lung Am J Physiol Heart Circ Physiol, published November 1, 2017. DOI: 10.1152/ajpheart.00206.2017

00:0000:00

Chinese - English Language Podcast on Differential Cardiac Remodeling in TAC vs AR

Special Dual Language Podcast in Chinese and English: What fascinating findings are presented on the differences between pressure overload and volume overload induced cardiac hypertrophy? Listen to this intriguing podcast as Professor Jie Liu from Shenzhen University of China interviews the corresponding authors Drs. Yunzeng Zou and Jian Wu from Fudan University of China, and the first author Dr Jieyun You from Tongji University, talking about their work on different phenotypic, functional and molecular adaptations in cardiac hypertrophy under different mechanical stress. The authors utilized a mouse model of pressure overload induced by transverse aortic constriction, and a newly developed mouse model of volume overload induced by aortic regurgitation, to make a comparative study on the differences between the two types of cardiac hypertrophy. What are the prominent differences between the two types of hypertrophy? Which hypertrophy seems more benign? What are the translational implications for personalized therapeutics for cardiac hypertrophy? Listen now and learn more. 

 

Jieyun You, Jian Wu, Qi Zhang, Yong Ye, Shijun Wang, Jiayuan Huang, Haibo Liu, Xiaoyan Wang, Weijing Zhang, Liping Bu, Jiming Li, Li Lin, Junbo Ge, and Yunzeng Zou Differential cardiac hypertrophy and signaling pathways in pressure versus volume overload Am J Physiol Heart Circ Physiol, published December 1, 2017. DOI: 10.1152/ajpheart.00212.2017

00:0000:00