Environmentally Persistent Free Radicals Increase Post Ischemic Dysfunction

What is the role of environmentally persistent free radicals (EPFRs) in increasing cardiac vulnerability to subsequent myocardial infarction ischemia/reperfusion injury? Guest Editor Loren Wold (The Ohio State University) interviews lead author Kurt Varner (Louisiana State University Health Sciences Center New Orleans) and content expert Kevin Lord (University of the Incarnate Word) in this lively and engaging podcast which explores the work by Burn et al. Using a nose-only inhalation technique, Burn and Varner sought to mimic “real world” air pollution exposure to EPRFs and reduce any potential inflammation response from intratracheal installation of particulate matter. Which components of particulate matter contribute most to oxidative stress? How does the work by Burn and Varner fit into next-generation tobacco products, such as e-cigarettes? Listen to find out.


Brendan R. Burn , Kurt J. Varner Environmentally persistent free radicals compromise left ventricular function during ischemia/reperfusion injury Am J Physiol Heart Circ Physiol, published May 1, 2015, DOI: 10.1152/ajpheart.00891.2014.

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