Ethanol Exposure Alters Early Cardiac Function in the Looping Heart: a Mechanism for Congenital Heart Defects?

Could the eye-opening results that a single dose of ethanol causes late-stage congenital heart defects in an avian model of Fetal Alcohol Syndrome lead to human clinical guidelines? It may be too early to tell, but the work by Karunamuni et al strives to find out. Listen as Associate Editor Leon De Windt (Maastricht University) interviews lead author Michiko Watanabe (Case Western Reserve University) and expert Wolfram Zimmermann (University Medical Center Goettingen) about this unique study which meshes cardiovascular physiology and biomedical engineering techniques, such as Doppler OCT, in an avian model of embryonic heart development correlating to the first trimester of human pregnancy. Can this open model of cardiogenesis lead to new interventional pacing techniques or rescue agents, such as folate, to restore or repair cardiac function in the embryo? Listen and learn.


Ganga Karunamuni, Shi Gu, Yong Qiu Doughman, Lindsy M. Peterson, Katherine Mai, Quinn McHale, Michael W. Jenkins, Kersti K. Linask, Andrew M. Rollins, Michiko Watanabe Ethanol exposure alters early cardiac function in the looping heart: a mechanism for congenital heart defects? Am J Physiol Heart Circ Physiol, published February 1, 2014, DOI: 10.1152/ajpheart.00600.2013.

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