Hypoxia Inducible Factor-alpha and Cancer Cachexia

How does cancer cachexia directly affect the heart? Listen as Deputy Editor Merry Lindsey (University of Mississippi Medical Center) tackles this question and more as she interviews lead author Loren Wold (The Ohio State University) and content expert Hemal Patel (VA San Diego Healthcare System, University of California San Diego) about the insightful study by Devine et al on cancer-induced cachexia and its effects on cardiac muscle structure and physiology. Using a proteomics approach, Wold and colleagues investigated how hypoxia inducible factor-1alpha served as a sensor for oxygen handling in the heart during cancer cachexia, a global hypoxic event. What strain and sex -dependent effects of tumor formation did Wold and co-authors observe in their model of cancer cachexia? Why was it significant that c-kit was elevated in the left ventricle of the tumor-bearing mice? Does lipid accumulation in the cachexia model bear resemblance to accelerated aging? Many questions, many answers. Listen now.

 

Raymond D. Devine, Sabahattin Bicer, Peter J. Reiser, Loren E. Wold Increased hypoxia-inducible factor-1α in striated muscle of tumor-bearing mice Am J Physiol Heart Circ Physiol, published June 1, 2017. DOI: 10.1152/ajpheart.00090.2016

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