Archive for July 2011

For fifty years, Guyton's venous return curves and their interpretation, presented in virtually every heart physiology text, have instructed as much as puzzled many students. Senior Associate Editor David Kass, leading expert John Tyberg (University of Calgary), and authors Daniel Beard (Medical College of Wisconsin) and Eric Feigl (University of Washington) set the record straight on how to understand basic cardiovascular physiology of the circulation, venous return into the heart, and the control of cardiac output. Medical students, physiologists, and physicians take note:  getting the pressure-volume relationship right has never been more important.


Daniel A. Beard and Eric O. Feigl. Understanding Guyton's Venous Return Curves Am J Physiol Heart Circ Physiol, published online ahead of print June 10, 2011; doi:10.1152/ ajpheart.00228.2011.

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A novel and unique large animal model illuminates why we should focus, for a change, on right ventricular cardiac disease and some of the changes that occur during development of right ventricular failure and pulmonary hypertension. Associate Editor Meredith Bond interviews authors Lori Walker and Peter Buttrick (both University of Colorado Denver), as well as leading expert JP Jin (Wayne State University) about this innovative study presented in the article by Walker et al.

Lori A. Walker, John Stephen Walker, Amelia Glazier, R. Dale Brown, Kurt R. Stenmark, and Peter M. Buttrick.Biochemical and myofilament responses of the right ventricle to severe pulmonary hypertension Am J Physiol Heart Circ Physiol, published online ahead of print May 27, 2011; doi:10.1152/ajpheart.00249.2011.

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