Archive for August 2011

Did physiology get lost in the genomics explosion? Our experts think not. Rather they champion the reemergence of physiology as the essential discipline required to make sense of the “omics” revolution. Join Editor in Chief William Stanley, leading experts Michael Joyner (Mayo Clinic) and Shawn Bender (University of Missouri), and authors Peter Wagner (University of California, San Diego) and David Paterson (University of Oxford), as they discuss how insights from the “omics” disciplines depend on physiology for translation into new biological concepts and clinical applications.

Peter D. Wagner and David J. Paterson. Physiology: Found in Translation Am J Physiol Heart Circ Physiol, published online ahead of print July 1, 2011, doi:10.1152/ajpheart.00649.2011.

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In our latest podcast, we investigate aortic valve disease and potential therapeutic interventions other than valvular replacement. Associate Editor Ivor Benjamin interviews authors Hanjoong Jo and Casey Holliday (Emory University) as well as leading expert Jordan Miller (Mayo Clinic) about the recently published article by Holliday et al, which probes the role of endothelial cells in the aortic valve and explores our understanding of mechanosensitive microRNAs responding to shear stress.


Casey J. Holliday, Randall F. Ankeny, Hanjoong Jo, and Robert M. Nerem.Discovery of shear- and side-specific mRNAs and miRNAs in human aortic valvular endothelial cells Am J Physiol Heart Circ Physiol published ahead of print June 24, 2011, doi:10.1152/ajpheart.00117.2011.

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Most physiologists would probably agree that delivery of oxygen to tissues is the single most important function of the cardiovascular system. And, most would assign this task to the capillaries. Surprisingly however, some studies have suggested a major role for arterioles instead. In our latest podcast Associate Editor W. Gil Wier interviews senior author Roland Pittman (Virginia Commonwealth University) and leading expert David Poole (Kansas State University) about the work of Golub et al, which provides some compelling new data on the issue, and also a reminder about the importance of critical evaluation of methodology.


Aleksander S. Golub, Bjorn K. Song, and Roland N. Pittman. The rate of oxygen loss from mesenteric arterioles is not unusually high Am J Physiol Heart Circ Physiol, published online ahead of print June 17, 2011, doi:10.1152/ajpheart.00353.2011.

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