We break it down for you: what really are the factors and mechanisms of cell replacement therapy? What are the mechanisms by which transplanted MSCs exert their paracrine effects? Associate Editor Ivor Benjamin interviews lead author Kathrin Banach (University of Illinois at Chicago) and expert Timothy Kamp (University of Wisconsin - Madison) about the recent work by Mureli et al, which has significant translational implications for cell therapy after ischemic injury. Listen and learn more..
Shwetha Mureli, Christopher P. Gans, Dan J. Bare, David L. Geenen, Nalin M. Kumar, and Kathrin Banach Mesenchymal Stem Cells Improve Cardiac Conduction by Up-Regulation of Connexin 43 Through Paracrine Signaling Am J Physiol Heart Circ Physiol, published online December 15, 2012, doi: 10.1152/ajpheart.00533.2012.