Archive for October 2013

Is 3D printing an attainable reality or a futuristic ideal? In their recently published Perspective, Sulkin et al argue that small-scale instrumentation manufacturing in plastic from a 3D desktop printer is not only here and now, but also affordable. Listen to our lively and engaging podcast as Consulting Editor Dr. Steven P. Jones interviews senior author Dr. Igor Efimov (Washington University in St. Louis) and leading expert Dr. Hee Cheol Cho (Cedars-Sinai Heart Institute) about ancient printing techniques, the inherent tinkering work methods of physiologists, open source design software programs, and surprisingly low-cost printing technology. Is a 3D desktop printer the future of cardiovascular research labs everywhere? Listen and find out.

Matthew S. Sulkin, Emily Widder, Connie C. Shao, Katherine M. Holzem, Christopher Gloschat, Sarah R. Gutbrod, Igor R. Efimov 3D Printing Physiology Laboratory Technology Am J Physiol Heart Circ Physiol, published online September 16, 2013, DOI: 10.1152/ajpheart.00599.2013.

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What is RSK3 and how can it help us uncover the underlying mechanisms of hypertrophic cardiomyopathy? Associate Editor Meredith Bond leads an engaging conversation between senior author Michael Kapiloff (University of Miami) and leading expert Nikolaos Frangogiannis (Albert Einstein College of Medicine) about the exciting new study by Passariello et al. Listen as we explore the clinical implications of targeting RSK3 as a crucial pathway in the pathogenesis of fibrosis. How can we translate the understanding of the mechanisms of RSK3 and its effect on cardiomyocytes and fibroblasts to targeted drug therapies for the nearly 5 million Americans—both children and adults—afflicted with left ventricular hypertrophy every year? Listen and learn more.

Catherine L. Passariello , Marjorie Gayanilo , Michael D. Kritzer , Hrishikesh Thakur , Zoharit Cozacov , Francesca Rusconi , David Wieczorek , Michael Sanders , Jinliang Li, Michael S. Kapiloff p90 ribosomal S6 kinase 3 contributes to cardiac insufficiency in α-tropomyosin Glu180Gly transgenic mice Am J Physiol Heart Circ Physiol, published online August 2, 2013, doi: 10.1152/ajpheart.00237.2013.

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Can early inhibition of the late sodium current slow hypertension-induced t-tubule disruption and calcium cycling defects that lead to heart failure? Join Editor in Chief William C. Stanley as he explores the innovative work by Aistrup et al with senior author J. Andrew Wasserstrom (Northwestern University Feinberg School of Medicine) and leading expert Guy Salama (University of Pittsburgh). Listen as they discuss the effects of chronic treatment with ranolazine on T-tube disruption and the development of heart failure.

Gary L. Aistrup, Deepak K. Gupta, James E. Kelly, Matthew J. O'Toole, Amanda Nahhas, Nimi Chirayil, Sol Misener, Lauren Beussink, Neha Singh, Jason Ng, Mahendra Reddy, Thitipong Mongkolrattanothai, Nesrine El-Bizri, Sridharan Rajamani, John C. Shryock, Luiz Belardinelli, Sanjiv J. Shah, J. Andrew Wasserstrom Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat Am J Physiol Heart Circ Physiol, published online July 19, 2013, doi: 10.1152/ajpheart.00401.2013.

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What is Mena? In this podcast we explore the innovative new work by Belmonte et al on the overexpression of Mammalian homologue of drosophila enabled (Mena) and its exacerbating effects on heart failure secondary to pressure overload. Listen as Associate Editor Ronglih Liao interviews senior author Burns Blaxall (Cincinnati Children's Hospital Medical Center) and leading expert in myocardial and cellular signaling Walter Koch (Temple University School of Medicine) about this intriguing work by Blaxall and colleagues, which explores the complexities of Mena in cellular regulation. How was Mena discovered? Does it play a role in coronary artery disease? Listen and find out.

Stephen L. Belmonte , Rashmi Ram , Deanne M. Mickelsen , Frank B. Gertler , Burns C. Blaxall Cardiac Overexpression of Mammalian enabled (Mena) Exacerbates Heart Failure in Mice Am J Physiol Heart Circ Physiol, published online July 5, 2013, DOI: 10.1152/ajpheart.00342.2013.

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