Why are in utero conditions so critical to cardiovascular health after birth? Listen as Associate Editor Ronglih Liao interviews lead author Loren Wold (Ohio State University) and expert Anne Knowlton (University of California, Davis) about the latest insightful work by Velten et al, which tests a “two-hit” hypothesis mouse model—inflammation followed by hyperoxia—to analyze how cardiac function is altered very early in life. Is Wold’s innovative work bringing the 18th century biologist Lamarck’s theory of inheritance of acquired characteristics front and center in 21st century cardiovascular physiology? Listen and find out.
Markus Velten, Matthew W. Gorr, Dane J. Youtz, Christina Velten, Lynette K. Rogers, Loren E Wold Adverse Perinatal Environment Contributes to Altered Cardiac Development and Function Am J Physiol Heart Circ Physiol, published online March 7, 2014. DOI: 10.1152/ajpheart.00056.2014.