Archive for January 2015

Diet, Sex and Exercise in Mice

Do you need to change your New Year’s dieting resolution? Maybe…according to a new study by Konhilas et al, who looked at the trifecta of soy-based versus casein-based diets, exercise, and sex differences in mice. In this engaging new podcast, Deputy Editor Merry L. Lindsey (University of Mississippi Medical Center) interviews lead author John Konhilas (University of Arizona) and expert Ganesh Halade (University of Alabama at Birmingham) about the complex work by Konhilas and colleagues which layered sex dimorphisms in exercise ability, over adaptation to disease and different elements of diet. Did the authors' waterfall of experiments show that diet and sex interact in an overall response to exercise? Listen now.

John P. Konhilas, Hao Chen, Elizabeth D. Luczak, Laurel A. McKee, Jessica Regan, Peter A. Watson, Brian L. Stauffer, Zain I. Khalpey, Timothy A. McKinsey, Todd R. Horn, Bonnie LaFleur, Leslie A. Leinwand Diet and sex modify exercise and cardiac adaptation in the mouse Am J Physiol Heart Circ Physiol, published January 15, 2015. DOI: 10.1152/ajpheart.00532.2014.

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What is causing vascular rarefaction in the skeletal muscle of patients with metabolic syndrome? In this podcast Associate Editor Gary Lopaschuk (University of Alberta) interviews lead author Jeff Frisbee (West Virginia University) and expert Victor Samokhvalov (University of Alberta) about the work by Frisbee and colleagues, which found that the chronic reduction in vascular nitric oxide bioavailability accompanying metabolic syndrome did not match the development of the rarefaction in skeletal muscle microcirculation. Using a multivariate discriminant model and leaning heavily on the concept of temporal resolution, the authors show that thromboxane and the inflammatory pathway may be the key mechanism for the initial pulse of vascular rarefaction. What potential therapeutic pathways does this open up? Listen now.

Jefferson C. Frisbee, Adam G. Goodwill, Stephanie J. Frisbee, Joshua T. Butcher, Robert W. Brock, I. Mark Olfert, Evan R. DeVallance, Paul D. Chantler Distinct temporal phases of microvascular rarefaction in skeletal muscle of obese Zucker rats Am J Physiol Heart Circ Physiol, published December 15, 2014. DOI: 10.1152/ajpheart.00605.2014.

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