Gestational Nanomaterial Exposure and Cardiac Dysfunction

Does exposure when pregnant to the nanomaterial titanium dioxide have an impact on progeny? Listen as Associate Editor Gary Lopaschuk (University of Alberta) interviews lead author John Hollander (West Virginia University School of Medicine) and content expert John Ussher (University of Alberta) about the recent study by Hathaway et al., which used a gestational animal model to determine if acute exposure to the nanomaterial titanium dioxide would affect fetal cardiac contractile function and bioenergetics. Hollander and co-authors found that bioenergetics are negatively impacted, which ultimately affected whole heart function and myocyte function in young adult animals. Since it is well known that metabolic enzymes and regulators of mitochondrial function are subject to epigenetic alterations, do the authors speculate that epigenetic modifications may play a role in the phenotype they observed? With engineered nanomaterials appearing in numerous commercial applications—from toothpaste to ceramic tiles—what other nanoparticles are important to study for potential short and long-term effects on progeny? Listen and find out.

 

Quincy A. Hathaway, Cody E. Nichols, Danielle L. Shepherd, Phoebe A. Stapleton, Sarah L. McLaughlin, Janelle C. Stricker, Stephanie L. Rellick, Mark V. Pinti, Alaeddin B. Abukabda, Carroll R. McBride, Jinghai Yi, Seth M. Stine, Timothy R. Nurkiewicz, John M. Hollander Maternal-engineered nanomaterial exposure disrupts progeny cardiac function and bioenergetics Am J Physiol Heart Circ Physiol, published March 1, 2017. DOI: 10.1152/ajpheart.00634.2016

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Interval Exercise and Flow-mediated Dilation

Does high-intensity interval training (HIIT) have any effects on blood vessel function in type 2 diabetes patients? In this engaging podcast, Consulting Editor Nisha Charkoudian (U.S. Army Research Institute of Environmental Medicine) interviews lead author Jonathan Little (University of British Columbia Okanagan) and content expert Ellen Dawson (Liverpool John Moores University) about the exciting new exercise training study by Francois et al. Little and co-authors compared a cardio-type HIIT workout of cycling to a resistance exercise HIIT workout, in both type 2 diabetes patients and healthy age-matched master athletes. Did the authors find the resistance HIIT was more effective at improving flow mediated dilation and endothelial function in type 2 diabetes (T2D) patients? The results of this study are consistent with a shift to considering T2D a vascular disease, and suggest that HIIT may be a practical exercise strategy for improving vascular function in T2D patients. Furthermore, could resistance-based HIIT solve the very real issue of patient compliance? After all, says Dawson, "We need people to be exercising, and the best kind of exercise is the one that they're going to continue to do."

 

Monique E. Francois, Cody Durrer, Kevin J. Pistawka, Frank A. Halperin, Jonathan P. Little Resistance-based interval exercise acutely improves endothelial function in type 2 diabetes Am J Physiol Heart Circ Physiol, published November 1, 2016. DOI: 10.1152/ajpheart.00398.2016

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