MicroRNA Translocation into the Mitochondria

In this podcast, we explore the exciting field of mitochondrial transcriptomics. Guest Editor John Hollander (West Virginia University School of Medicine) interviews lead author Samarjit Das (Johns Hopkins University) and content expert Paras Mishra (University of Nebraska Medical Center) about the new Review by Anne Macgregor-Das and Samarjit Das which expands our understanding of the intersection between mitochondria and non-coding RNAs. The mitochondrial genome only contains 13 protein encoding genes. Questions abound: Why are so many microRNAs found in the mitochondria, and do they all bind to mitochondrial mRNAs? What percentage of mitomereres are directly involved in the regulation of the mitochondrial genome? What diseases do our experts envision benefitting from microRNA therapeutics in the near future? Listen to find the answers.

 

Anne M. Macgregor-Das and Samarjit Das A microRNA's Journey to the Center of the Mitochondria Am J Physiol Heart Circ Physiol, published March 23, 2018. DOI: 10.1152/ajpheart.00452.2017

Exercise Training Increases GCH1 and Couples eNOS in Heart Failure

What is the mechanisms for the beneficial effects of exercise on coronary artery function in heart failure? Associate Editor Nancy Kanagy (University of New Mexico School of Medicine) interviews lead author Luciana Venturini Rossoni (University of Sao Paulo Biomedical Sciences Institute) and content expert Shane Phillips (University of Illinois-Chicago) about the fascinating new work by Couto et al in this engaging podcast. What mechanisms mediate the beneficial effects of aerobic exercise after heart failure? What role does tetrahydrobiopterin play in restoring coronary artery dilatory function? Listen and find out.

 

Gisele K. Couto, Suliana M. Paula, Igor L. Gomes-Santos, Carlos Eduardo Negrão, and Luciana V. Rossoni Exercise training induces eNOS coupling and restores relaxation in coronary arteries of heart failure rats Am J Physiol Heart Circ Physiol, published April 9, 2018. DOI: 10.1152/ajpheart.00624.2017