Reversal of Microvascular Dysfunction

Can existing vascular disease be reversed? Listen as Associate Editor Robert Hester (University of Mississippi Medical Center) interviews lead author Jefferson Frisbee (University of Western Ontario) and content expert Geraldine Clough (University of Southampton) about the novel new work by Lemaster et al, which utilized a chronically obese animal model to attempt to reverse established vascular dysfunction rather than blunt disease development. After treatment with chronic atorvastatin, or chronic treadmill exercise, or both, Frisbee and colleagues observed improvement in endothelial function, however with some residual vasculopathy. What unique insights were gained by using a multi-scale approach from whole animal to isolated tissues? Do these observations have translational implications for treatment of microvascular dysfunction in patients? Listen and find out.

 

Kent A Lemaster, Stephanie J Frisbee, Luc DuBois, Nikolaos Tzemos, Fan Wu, Matthew T Lewis, Robert W. Wiseman, and Jefferson C. Frisbee Chronic Atorvastatin and Exercise Can Partially Reverse Established Skeletal Muscle Microvasculopathy in Metabolic Syndrome  Am J Physiol Heart Circ Physiol. Published June 22, 2018. DOI: 10.1152/ajpheart.00193.2018

Fibroblast Phenotypic Changes in the Aging Heart

Why is it important to understand resident cardiac fibroblasts and how they change with aging? In this thought-provoking podcast, Deputy Editor Merry Lindsey (University of Mississippi Medical Center) interviews lead author Katarzyna Cieslik (Baylor College of Medicine) and content expert Michael Czubryt (University of Manitoba) about the insightful Review article by Trial and Cieslik. Fibroblasts are no longer considered mere support cells producing matrix protein, explains Cieslik. Rather, fibroblasts have complex physiology and a phenotype altered by aging. Listen as our experts unravel the many faces of fibroblasts, from promoting inflammation to producing extracellular matrix protein. Can observations made in young healthy fibroblasts be extrapolated across ages and pathologies? Listen and find out.

 

JoAnn Trial and Katarzyna A. Cieslik Changes in Cardiac Resident Fibroblast Physiology and Phenotype in Aging Am J Physiol Heart Circ Physiol, published June 15, 2018. DOI: 10.1152/ajpheart.00237.2018