Archive for August 2020

Assessment of Diastolic Function

Listen as Deputy Editor Merry Lindsey (University of Nebraska Medical Center) interviews authors Leslie Ogilvie and Jeremy Simpson (University of Guelph) and expert Michael Czubryt (University of Manitoba) about the recent Review by Ogilvie et al. on the importance of evaluating best practices in the hemodynamic assessment of diastolic function for animal models. With significant clinical focus on the role diastolic dysfunction plays in heart failure with preserved ejection fraction (HFpEF), cardiac fibrosis, and diabetes, there is no better time to examine diastolic functional assessments in experimental models. “Diastolic function has emerged as being equally important to systolic function in the overall ability of the heart to function as a pump,” explains Simpson. We discuss rodent models of human diastolic dysfunction in the setting of HFpEF, and understanding diastolic function in terms of its two phases—relaxation and filling. What recommendations do Ogilvie and Simpson make for handling the inherent limitations of software-based algorithms? Listen and learn more.


Leslie M. Ogilvie, Brittany A. Edgett, Jason S. Huber, Mathew J. Platt, Hermann J. Eberl, Sohrab Lutchmedial, Keith R. Brunt, Jeremy A. Simpson Hemodynamic assessment of diastolic function for experimental models Am J Physiol Heart Circ Physiol, published April 21, 2020. DOI: ajpheart.00705.2019

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Race, Blood Pressure, and Microvascular Function

Does pre-hypertension, or Stage 1 hypertension, have adverse effects on the microvasculature and the ability of blood vessels to vasodilate? In this episode, Associate Editor Nisha Charkoudian (U.S. Army Research Institute of Environmental Medicine) interviews lead author Brett Wong (Georgia State University) and expert Anna Stanhewicz (University of Iowa) about the new study by Wong and co-authors, in which a local heating protocol on the skin was used to investigate whether race and/or blood pressure affect sensory nerve function. The authors found that both sensory nerve function and microvascular nitric oxide function were reduced in pre-hypertensive non-Hispanic black study participants compared to non-Hispanic white study participants. Even in the absence of overt cardiovascular disease, the work by Wong and co-authors detected changes in the mechanisms controlling blood flow. How do the racial differences observed in this study challenge the “one size fits all” concept of preventative cardiovascular healthcare? Listen now.


Brett J. Wong, Casey G. Turner, James T. Miller, Demetria C. Walker, Yesser Sebeh, Matthew J. Hayat, Jeffrey S. Otis, Arshed A. Quyyumi Sensory nerve-mediated and nitric oxide-dependent cutaneous vasodilation in normotensive and prehypertensive non-Hispanic blacks and whites Am J Physiol Heart Circ Physiol, published July 14, 2020. DOI:

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