Archive for December 2020

Sleep Deprivation and Endothelial Function

Sleep disorders, such as insomnia, sleep apnea and restless leg syndrome, have acute and chronic negative cardiovascular impacts. Why is so little known about the cellular and molecular mechanisms regulating cardiovascular events in sleep disorders? In this podcast Editor-in-Chief Dr. Irving H. Zucker interviews lead author Dr. Maureen MacDonald (McMaster University) and expert Karyn Esser (University of Florida) about an insightful new Review article by Cherubini et al. MacDonald and co-authors became interested in the affect sleep has on endothelial function while conducting their own exercise physiology studies. Reviewing the literature, Cherubini et al. found that most studies do not control for sleep, yet sleep deprivation – whether acute or chronic, partial or total – can have negative effects on endothelial function in humans. The literature also shows similar results in animal and cell culture models. Because clock mechanisms exist in every human cell type, the understanding of links between so-called “clock genes” and disease progression is an emerging field. How does this relate to the development of atherosclerotic plaques, and the potential for exercise as a therapeutic strategy to combat the negative impact of disordered sleep? Listen now.


Joshua M. Cherubini, Jem L. Cheng, Jennifer S Williams, Maureen J. MacDonald Sleep deprivation and endothelial function: reconciling seminal evidence with recent perspectives  Am J Physiol Heart Circ Physiol, published October 16, 2020. DOI:

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Behind the Bench Episode7

Why should medical school students invest their time in basic science research? That’s our theme for this episode of Behind the Bench from AJP-Heart and Circ. Hosts Lisandra de Castro Brás (East Carolina University) and Jonathan Kirk (Loyola University Chicago) interview Dhandevi Persand and Nicole Maddie, both students at the New York Institute of Technology College of Osteopathic Medicine. Dhandevi and Nicole won the FASEB Dream Award to attend the APS Professional Skills Training Course on Writing and Reviewing for Scientific Journals, and they have co-authored a New Investigator Editorial detailing their experiences. More importantly, Dhandevi and Nicole are using their platform as Women in Stem to promote the importance of research for clinical trainees. As students in the NYIT Doctor of Osteopathic Medicine (D.O.) program, Nicole and Dhandevi focus on how structure affects function. The translational research projects they have both worked on have cemented their feelings that research is critically important for medical students and clinicians. Did you know that D.O. students must complete 200 additional hours of coursework, compared to M.D. students, in order to learn osteopathic manipulative medicine? Listen for a refreshingly open conversation about time management and reaching for “stretch goals” which turn out to be surprisingly attainable.


Dhandevi Persand and Nicole Maddie New investigator editorial: the osteopathic medical student perspective on research Am J Physiol Heart Circ Physiol, published December 2, 2020. DOI:

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