AJP-Heart and Circulatory Physiology Podcasts
Behind the Bench Episode 9

Behind the Bench Episode 9

August 25, 2021

How does a single intriguing patient encounter lead to a clinical research career investigating extreme premature birth history and increased risk of cardiopulmonary complications later in life? In this new episode of Behind the Bench with AJP-Heart and Circ, co-hosts Lisandra de Castro Brás (East Carolina University) and Charlotte Usselman (McGill University) interview Kara Goss (University of Texas Southwestern) about the fascinating study by Corrado et al. Admittedly inspired by her own experience as a mother to two children, both of whom were born prematurely, our producer Kara Hansell Keehan wanted to dig deeper into this latest work by Goss and co-authors. An early inspiration for Goss was her clinical rotation in the NICU, yet she followed a different clinical path into adult critical cardiopulmonary care. It was ultimately a single encounter with an older patient in acute cardiopulmonary distress who had, as Goss uncovered, a preterm birth history, that changed her career path. Thus, a research career was born (pun intended). Why did Goss and co-authors find right ventricular, but not left ventricular, dysfunction in this former preemie adult cohort? Is exercise the key to mitigating the effects of this right ventricular function? This podcast episode is simply fascinating, so listen now.

 

Philip A. Corrado, Gregory P. Barton, Christopher J. Francois, Oliver Wieben, and Kara N. Goss Sildenafil administration improves right ventricular function on 4D flow MRI in young adults born premature Am J Physiol Heart Circ Physiol, published May 20, 2021. DOI: doi.org/ 10.1152/ajpheart.00824.2020

Txnip C247S Mutation Improves Cardiac Function in Diabetes

Txnip C247S Mutation Improves Cardiac Function in Diabetes

August 6, 2021

This is a story about a good guy (thioredoxin) vs. a bad guy (Txnip). Consulting Editor Paras Mishra (University of Nebraska Medical Center) interviews lead author Jun Yoshioka (City University of New York) and expert Rebecca Ritchie (Monash University) about the latest research by Yoshioka and co-authors. As the underlying basis of diabetic cardiomyopathy remains unclear, Mukai et al. focused on the pathway connecting hyperglycemia to oxidative stress. Thioredoxin is an antioxidant molecule which uses catalytic sites at cysteine 32 and 35 to reduce target proteins and detoxify oxidative stress. The villain Txnip, an endogenous inhibitor of thioredoxin and its antioxidative properties, acts as a pro-oxidant. A high level of extracellular glucose strongly upregulates Txnip. “If glucose induces Txnip, and Txnip is a bad guy killing cells, then the obvious question is: does Txnip mediate diabetes-induced cellular damage?” explains Yoshioka. What’s the answer? Listen now.

 

Nobuhiro Mukai, Yoshinobu Nakayama, Syed Amir Abdali, Jun Yoshioka Cardiomyocyte-specific Txnip C247S mutation improves left ventricular functional reserve in streptozotocin-induced diabetic mice Am J Physiol Heart Circ Physiol, published June 4, 2021. DOI: 10.1152/ajpheart.00174.2021

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