AJP-Heart and Circulatory Physiology Podcast

Nitric oxide, prostanoids, and oxygen consumption in the human skeletal muscle

Another exciting installment in our AJP-Heart and Circ podcast series takes us to the icy climes of Finland to discuss the article by Heinonen et al regarding NO regulation of muscle blood flow and metabolism using heroic PET studies. Joining our Editor in Chief William C. Stanley is lead author Ilkka Heinonen (University of Turku, Finland) and expert Michael Joyner (Mayo Clinic). Heinonen Ilkka, Saltin Bengt, Kemppainen Jukka, Hannu T. Sipilä, Oikonen Vesa, Nuutila Pirjo, Knuuti Juhani, Kalliokoski Kari, and Hellsten Ylva. Skeletal muscle blood flow and oxygen uptake at rest and during exercise in humans: a PET study with nitric oxide and cyclooxygenase inhibition. Am J Physiol Heart Circ Physiol 300: H1510-H1517, 2011.

Nonmyocyte apoptosis and LV hypertrophy

Listen as our Editor in Chief William C. Stanley interviews lead author Stephen F. Vatner (University of Medicine and Dentistry of New Jersey) and expert Joseph A. Hill (University of Texas Southwestern Medical Center) with an intellectual yet entertaining discussion of the recently published article by Gelpi et al on non-myocyte apoptosis and LV hypertrophy. Ricardo J. Gelpi, Misun Park, Shumin Gao, Sunil Dhar, Dorothy E. Vatner, and Stephen F. Vatner. Apoptosis in severe, compensated pressure overload predominates in non-myocites and is related to the hypertrophy but not function. Am J Physiol Heart Circ Physiol 300: H1062-H1068, 2011.

Blood pressure, BH4, and vascular NOS signalling

Our second installment in the 2011 podcast series discusses the recently published article by Kang et al on blood pressure, BH4, and vascular NOS signaling. Listen as our Senior Associate Editor David A. Kass dives into the core of this article, and engages lead author Jennifer Pollock and expert Michael Wolin in a lively roundtable discussion of this interesting and important work. Then navigate to the Editorial Focus by Judy Lin and An Moens for more insights and commentary on the Kang et al article. Kyu-Tae Kang, Jennifer C. Sullivan, Frank T. Spradley, Livius V. d'Uscio, Zvonimir S. Katusic, and Jennifer S. Pollock. Anti-hypertensive therapy increases BH4 levels and NO/cGMP signaling in small arteries of angiotensin II-infused hypertensive rats. Am J Physiol Heart Circ Physiol; 300: H718-H724; 2011. Editorial Focus:  Judy Y. Lin and An L. Moens. Tetrahydrobiopterin and hypertension: more than an emigrating story. Am J Physiol Heart Circ Physiol 300: H715; 2011.

Inaugural Podcast: Quality and Innovation

To launch our new AJP‐Heart and Circ podcast series, we introduce Dr. William C. Stanley as our new Editor in Chief and engage in a light‐hearted roundtable discussion about AJP‐Heart and Circ and the exciting new initiatives and features Dr. Stanley and his new editorial team have planned for their readers.

Biochemical and myofilament responses of the right ventricle to severe pulmonary hypertension

A novel and unique large animal model illuminates why we should focus, for a change, on right ventricular cardiac disease and some of the changes that occur during development of right ventricular failure and pulmonary hypertension. Associate Editor Meredith Bond interviews authors Lori Walker and Peter Buttrick (both University of Colorado Denver), as well as leading expert JP Jin (Wayne State University) about this innovative study presented in the article by Walker et al.

Lori A. Walker, John Stephen Walker, Amelia Glazier, R. Dale Brown, Kurt R. Stenmark, and Peter M. Buttrick.Biochemical and myofilament responses of the right ventricle to severe pulmonary hypertension Am J Physiol Heart Circ Physiol, published online ahead of print May 27, 2011; doi:10.1152/ajpheart.00249.2011.

Biochemical and myofilament responses of the right ventricle to severe pulmonary hypertension

A novel and unique large animal model illuminates why we should focus, for a change, on right ventricular cardiac disease and some of the changes that occur during development of right ventricular failure and pulmonary hypertension. Associate Editor Meredith Bond interviews authors Lori Walker and Peter Buttrick (both University of Colorado Denver), as well as leading expert JP Jin (Wayne State University) about this innovative study presented in the article by Walker et al.

Lori A. Walker, John Stephen Walker, Amelia Glazier, R. Dale Brown, Kurt R. Stenmark, and Peter M. Buttrick.Biochemical and myofilament responses of the right ventricle to severe pulmonary hypertension Am J Physiol Heart Circ Physiol, published online ahead of print May 27, 2011; doi:10.1152/ajpheart.00249.2011.

Biochemical and myofilament responses of the right ventricle to severe pulmonary hypertension

A novel and unique large animal model illuminates why we should focus, for a change, on right ventricular cardiac disease and some of the changes that occur during development of right ventricular failure and pulmonary hypertension. Associate Editor Meredith Bond interviews authors Lori Walker and Peter Buttrick (both University of Colorado Denver), as well as leading expert JP Jin (Wayne State University) about this innovative study presented in the article by Walker et al.

Lori A. Walker, John Stephen Walker, Amelia Glazier, R. Dale Brown, Kurt R. Stenmark, and Peter M. Buttrick.Biochemical and myofilament responses of the right ventricle to severe pulmonary hypertension Am J Physiol Heart Circ Physiol, published online ahead of print May 27, 2011; doi:10.1152/ajpheart.00249.2011.