Angiogenic Exosomes from Vascular Progenitor Cells

Where did the search to find exosome donor cells lead the authors of the new study by Johnson et al? Editor in Chief Irving H. Zucker (University of Nebraska Medical Center) interviews authors Dong Liu (Morehouse School of Medicine) and Takerra Johnson (National Institutes of Health/ National Eye Institute), along with content expert Jean-Pyo Lee (Tulane University), about this novel study which utilized induced vascular progenitor cells as exosome donor cells to promote angiogenesis. The authors determined that secretion is more important to endothelial cells than differentiation, because secretion includes growth factors, cytokines, and exosomes. Compared to rat aortic endothelial cells, induced vascular progenitor cells have a greater secretion of exosomes. Johnson et al found that iVPCs promoted angiogenesis in a rat hindlimb ischemia model. What did the authors uncover when they investigated the microRNA cargo carried by iVPC exosomes? Listen and learn more.

 

Takerra K. Johnson, Lina Zhao, Dihan Zhu, Yang Wang, Yan Xiao, Babayewa Oguljahan, Xueying Zhao, Ward G. Kirlin, Liya Yin, William M. Chilian, and Dong Liu Exosomes derived from induced vascular progenitor cells promote angiogenesis in vitro and in an in vivo rat hindlimb ischemia model Am J Physiol Heart Circ Physiol, published October 1, 2019. DOI: doi.org/10.1152/ajpheart.00247.2019