Angiotensin II and Reflex Vasoconstriction with Age

What are the key age-related differences in the reflex vasoconstrictor response in skin microvessels, and how are angiotensin II and Rho-kinase activation involved? These questions and more are answered in our latest podcast on the work by Lang and Kolb. Listen as Associate Editor Debra Diz (Wake Forest University School of Medicine) interviews lead author James Lang (Des Moines University) and content expert Caitlin Thompson-Torgerson (Anne Arundel Community College) about this intriguing work which has clear thermoregulatory ramifications for older adults. Is there a potential upstream role for reactive oxygen species in upregulating Angiotensin II? How can the primary effects of aging in a healthy older adult cohort be extrapolated to disease states such as diabetes? Listen to find out.

James A. Lang , Kelsey E. Kolb Angiotensin II type I receptor blockade attenuates reflex cutaneous vasoconstriction in aged but not young skin Am J Physiol Heart Circ Physiol, published May 15, 2015, DOI: 10.1152/ajpheart.00017.2015.