Caveolin-1 and Angiotensin Receptor Interaction in Obesity

What is the role of angiotensin receptor trafficking in small artery constriction, and what is its contribution to obesity-associated microvascular dysfunction? In this podcast Associate Editor Fabio Recchia (Temple University and Scuola Superiore S. Anna, Pisa) interviews lead author Zsolt Bagi (Georgia Regents University) and content expert Prasad Katakam (Tulane University School of Medicine) about the novel work by Czikora et al., which explores the hypothesis that the interaction between type 1 angiotensin II receptor and caveolin-1 is essential to prevent sustained angiotensin-II induced constriction in resistance arteries. Given the close association between obesity and hypertension, are there potential clinical applications for this work, with the goal to help restore normal regulatory function of caveolin-1 in obese human patients? Listen and learn.

Istvan Czikora, Attila Feher, Rudolf Lucas, David J. R. Fulton, Zsolt Bagi Caveolin-1 prevents sustained angiotensin II-induced resistance artery constriction and obesity-induced high blood pressure Am J Physiol Heart Circ Physiol, published March 1, 2015. DOI: 10.1152/ajpheart.00649.2014.