Cell-Based Therapy for Prevention and Reversal of Myocardial Remodeling

Where are the prospects for cell-based therapies for myocardial infarction and heart failure? Listen as Editor in Chief William C. Stanley discusses stem cell therapies for heart disease and the new Review article by Karantalis et al with senior author Joshua Hare (University of Miami) and leading expert Jianyi (Jay) Zhang (University of Minnesota). This paper thoroughly examines cell-based therapies for treatment of acute myocardial infarction and chronic ischemic cardiomyopathy. What are the prospects for moving cell therapies out of the lab and into routine clinical practice?

Vasileios Karantalis, Wayne Balkan, Ivonne Hernandez Schulman, Konstantinos Hatzistergos, and Joshua M. Hare Cell-Based Therapy for Prevention and Reversal of Myocardial Remodeling Am J Physiol Heart Circ Physiol, published online May 25, 2012, doi: 10.1152/ajpheart.00221.2012.