Cortical Bone Derived Stem-Cell Therapy Reduces Apoptosis

How do cortical bone derived stem cells reduce scar size and improve cardiac function following myocardial infarction? Guest Editor Lorrie Kirshenbaum (St. Boniface General Hospital Research Centre) interviews authors Steven Houser (Temple University) and Alexander Hobby (Temple University), along with Associate Editor Junichi Sadoshima (Rutgers New Jersey Medical School), about the innovative new study by Hobby et al showing CBSCs reduce apoptosis of both myocytes and non-myocytes in a large animal model of reperfusion injury. Hobby et al found that CBSCs increased the number of T cells and macrophages in the heart, which may mean that the cardioprotective effects of CBSCs could be mediated through T cells. What do our experts have to say about the overall state of stem cell therapy, how CBSCs differ from other conventional types of stem cells, and the potential clinical application of CBSCs for post-MI wound healing? Listen now.

 

Alexander R. H. Hobby, Thomas E. Sharp 3rd, Remus M. Berretta, Giulia Borghetti, Eric Feldsott, Sadia Mohsin, Steven R. Houser Cortical bone-derived stem cell therapy reduces apoptosis after myocardial infarction Am J Physiol Heart Circ Physiol, published October 7, 2019. DOI: doi.org/10.1152/ajpheart.00144.2019