Differential vascular dysfunction in insulin resistance

Two things are clear—there is a global epidemic in obesity, and physical exercise is an effective means to combat it. Listen as Editor in Chief William C. Stanley and expert Robert Hester(University of Mississippi) interview lead author Shawn Bender (University of Missouri, Columbia). Bender and co-authors followedinsulin resistance in genetically obese rats. After spontaneous and vigorous periodic exercise, Bender et al recorded a normalization of body fat, reduction in glucose, and a decreased insulin resistance. Shawn B. Bender, Sean C. Newcomer, and M. Harold Laughlin. Differential vulnerability of skeletal muscle feed arteries to dysfunction in insulin resistance: impact of fiber type and daily activity. Am J Physiol Heart Circ Physiol 300: H1434-H1441, 2011.