Mechanotransduction and Redox Signals

Why cover only one article in a podcast, when we can discuss five articles at once? In this podcast on a unique Review article, Associate Editor Nancy Kanagy (University of New Mexico) interviews senior author and symposium organizer Shampa Chatterjee (University of Pennsylvania) and leading expert Mark Nelson (University of Vermont) about five reports presented at the 1st Pan American Congress of Physiological Sciences: Physiology Without Borders held in August 2014 in Iguassu Falls, Brazil. Under the umbrella topic of mechanosignaling and downstream redox-dependent responses, what links the mechanical forces at the cell membrane to the intracellular responses? Several key new findings were presented at the meeting. Among them, researchers have found that numerous elements on the cytoskeleton, such as PECAM and caveolae (caveolin-1), work together to form a mechanosome. Is the key to understanding the response to mechanosensing defining the machinery within the multifarious mechanosomes? How do we translate observations in cultured cells to responses in intact tissues and animals? Listen and learn.

Shampa Chatterjee, Keigi Fujiwara, Nestor G. Perez, Masuko Ushio-Fukai, Aron B. Fisher Mechanosignaling in the Vasculature: Emerging Concepts in Sensing, Transduction and Physiological Responses Am J Physiol Heart Circ Physiol, published online April 11, 2015, DOI: 10.1152/ajpheart.00105.2015.