Mitochondrial Adaptations and Myocardial Energetics

The protective effect of ischemic preconditioning lasts for only a few hours, then reappears about a day later in what is termed the Second Window of Protection (SWOP). In this podcast Editor in Chief William Stanley interviews senior author Edward McFalls (VA Medical Center, University of Minnesota) and leading expert Nazareno Paolocci (Johns Hopkins University) about the work by Cabrera et al, which brings together an elegant animal model, cutting-edge proteomics technology, and clinical cardiologist and cardiovascular physiologist to uncover the role of the mitochondria and energetics in mediating SWOP.

Jesus A Cabrera, Elizabeth A Ziemba, Robert Colbert, Lorraine Anderson, Willem Sluiter, Dirk J. Duncker, Tammy A Butterick, Joseph Sikora, Herbert B Ward, Rosemary F Kelly, and Edward O McFalls. Altered Expression of Mitochondrial Electron Transport Proteins and Improved Myocardial Energetic State During Late Ischemic Preconditioning Am J Physiol Heart Circ Physiol, published ahead of print March 2, 2012, doi: 10.1152/ajpheart.00372.2011.