Mitochondrial Function in the Ischemic Human Heart

Assessment of cardiac mitochondrial function in patients with chronic ischemic heart disease is rarely undertaken, but ultimately these measurements provide the final word in our understanding of the pathology of myocardial bioenergetics. In this new podcast, Editor in Chief William Stanley interviews lead author Flemming Dela (University of Copenhagen) and expert Ethan Anderson (East Carolina University) about the clinical studies by Stride et al. Listen as we gain new insights into the challenges of obtaining samples from human ventricle tissue, and discuss the experimental hurdles faced by researchers in this field. Will the next steps uncover new ways to manipulate mitochondria to lessen ischemia injury? Listen and find out.

Nis Stride, Steen Larsen, Martin Hey-Mogensen, Christina Neigaard Hansen, Clara Prats, Daniel Steinbrüchel, Lars Køber, and Flemming Dela Impaired Mitochondrial Function in Chronically Ischemic Human Heart Am J Physiol Heart Circ Physiol, published online March 29, 2013, doi: 10.1152/ajpheart.00991.2012.