Myocardial Dysfunction in Prediabetes

What are the functional and molecular mechanisms underlying prediabetes? Listen as Consulting Editor Michael Wolin (New York Medical College) interviews lead author Zoltan Giricz (Semmelweis University, Hungary) and content expert Hemal Patel (VA San Diego Healthcare System, University of California, San Diego) about the intriguing new work by Koncsos et al, which used a non-genetic rodent model of prediabetes to assess the deterioration of cardiac function in prediabetes caused by disturbances in multiple cellular processes, including mitochondrial oxidative stress. Why did the authors choose a high-fat diet model rather than a genetic model of prediabetes? Is oxidant stress at the sub-sarcolemmal mitochondria level the trigger point for downstream cardiovascular dysfunction? Listen and learn.

Gábor Koncsos, Zoltan V Varga, Tamas Baranyai, Kerstin Boengler, Susanne Rohrbach, Ling Li, Klaus-Dieter Schluter, Rolf Schreckenberg, Tamás Radovits, Attila Oláh, Csaba Mátyás, Árpád Lux, Mahmoud Al-Khrasani, Tímea Komlódi, Nóra Bukosza, Domokos Máthé, László Deres, Monika Barteková, Tomáš Rajtík, Adriana Adameová, Krisztián Szigeti, Péter Hamar, Zsuzsanna Helyes, László Tretter, Pal Pacher, Béla Merkely, Zoltán Giricz, Rainer Schulz, Péter Ferdinandy Diastolic dysfunction in prediabetic male rats: Role of mitochondrial oxidative stress Am J Physiol Heart Circ Physiol, published October 1, 2016. DOI: 10.1152/ajpheart.00049.2016