Post-translational Modifications of Cardiac Proteasomes

What are the big questions surrounding our understanding of post-translational modifications (PTMs) of proteasomes? Associate Editor Meredith Bond interviews lead author Nobel Zong (UCLA) and expert Xuejun Wang (University of South Dakota) about the latest Review article by Scruggs et al from the lab of Peipei Ping and colleagues. Why are the reversible and permanent PTMs of proteasomes critical to our understanding of cardiac physiology? How will we correlate changes in PTMs of proteasomes with pathological and physiological changes in heart function? How will we deal with the increasingly large data sets generated? Listen now…

Sarah B. Scruggs, Nobel C. Zong, Ding Wang, Enrico Stefani, and Peipei Ping Post-translational Modification of Cardiac Proteasomes: Functional Delineation Enabled by Proteomics Am J Physiol Heart Circ Physiol, published online April 20, 2012, doi: 10.1152/ajpheart.00189.2012.