TPPU-Reversible Alterations of Renin Angiotensin System

High fructose consumption is associated with metabolic syndrome, but the mechanisms are not well understood. Listen as Associate Editor Fabio Recchia (Temple University and Scuola Superiore Sant'Anna) interviews lead author An Huang (New York Medical College) and content expert Zsolt Bagi (Medical College of Georgia) about the new study by Froogh et al, which used an animal model to test the hypothesis that a high fructose diet elicits a chymase-dependent increase in angiotensin II production and oxidative stress. In this technical tour de force of a podcast, we unpack the complexities of EET as a protective factor against oxidative stress. Listen as our experts discuss metabolic syndrome in the context of COVID-19, as well as the potential clinical translation of chymase and soluble epoxide hydrolase as therapeutic targets for the treatment of metabolic syndrome.

 

Ghezal Froogh, Sharath Kandhi, Roopa Duvvi, Yicong Le, Zan Weng, Norah Alruwaili, Jonathan O. Ashe, Dong Sun, An Huang The contribution of chymase-dependent formation of ANG II to cardiac dysfunction in metabolic syndrome of young rats: roles of fructose and EETs Am J Physiol Heart Circ Physiol, published April 2, 2020. DOI: doi.org/10.1152/ ajpheart.00633.2019