How does TIMP-4 really behave in the myocardium, and what is its role in the pressure overload response to transverse aortic constriction? In this engaging author interview, Deputy Editor Merry Lindsey talks with lead author Francis Spinale (University of South Carolina School of Medicine and WJB Dorn VA Medical Center) and expert Zamaneh Kassiri (University of Alberta) about the work by Yarbrough et al, which surprisingly showed that inducing TIMP-4 in the setting of pressure overload may be beneficial. Have Spinale and colleagues opened the door to a sea-change in the current canonical thinking of TIMP roles? Listen and find out.
William M. Yarbrough, Catalin F. Baicu, Rupak Mukherjee, An O. Van Laer, William T. Rivers, Richard A. McKinney, Corey B. Prescott, Robert E. Stroud, Parker D. Freels, Kia N. Zellars, Michael R. Zile, Francis G. Spinale Cardiac Restricted Overexpression Or Deletion Of Tissue Inhibitor Of Matrix Metalloproteinase-4 Am J Physiol Heart Circ Physiol, published online July 3, 2014. DOI: 10.1152/ajpheart.00063.2014.