While wave separation analysis is considered the gold standard for assessing pressure and flow waves in the arterial system, how do we account for self-cancelling flow waves during diastole? In this podcast Associate Editor Dr. Masafumi Kitakaze interviews lead author Jonathan Mynard (Murdoch Children’s Research Institute, Australia) and expert Berend Westerhof (Edwards Lifesciences BMEYE, Netherlands) about the innovative work by Mynard and co-author Joseph Smolich, which used mathematical models and experimental studies in sheep to discover the novel concepts of wave potential and the one-dimensional windkessel. With attention now being paid to the origin and behavior of self-cancelling diastolic waves, we may be poised to better understand the relationship between pressure and flow in cardiovascular health and disease states. Listen now and learn more.
Jonathan P Mynard , Joseph J. Smolich Wave potential and the one-dimensional windkessel as a wave-based paradigm of diastolic arterial hemodynamics Am J Physiol Heart Circ Physiol, published May 30, 2014. DOI: 10.1152/ajpheart.00293.2014.