Nonmyocyte apoptosis and LV hypertrophy

Listen as our Editor in Chief William C. Stanley interviews lead author Stephen F. Vatner (University of Medicine and Dentistry of New Jersey) and expert Joseph A. Hill (University of Texas Southwestern Medical Center) with an intellectual yet entertaining discussion of the recently published article by Gelpi et al on non-myocyte apoptosis and LV hypertrophy.

Ricardo J. Gelpi, Misun Park, Shumin Gao, Sunil Dhar, Dorothy E. Vatner, and Stephen F. Vatner. Apoptosis in severe, compensated pressure overload predominates in non-myocites and is related to the hypertrophy but not function. Am J Physiol Heart Circ Physiol 300: H1062-H1068, 2011.

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Blood pressure, BH4, and vascular NOS signalling

Our second installment in the 2011 podcast series discusses the recently published article by Kang et al on blood pressure, BH4, and vascular NOS signaling. Listen as our Senior Associate Editor David A. Kass dives into the core of this article, and engages lead author Jennifer Pollock and expert Michael Wolin in a lively roundtable discussion of this interesting and important work. Then navigate to the Editorial Focus by Judy Lin and An Moens for more insights and commentary on the Kang et al article.

Kyu-Tae Kang, Jennifer C. Sullivan, Frank T. Spradley, Livius V. d'Uscio, Zvonimir S. Katusic, and Jennifer S. Pollock. Anti-hypertensive therapy increases BH4 levels and NO/cGMP signaling in small arteries of angiotensin II-infused hypertensive rats. Am J Physiol Heart Circ Physiol; 300: H718-H724; 2011.

Editorial Focus:  Judy Y. Lin and An L. Moens. Tetrahydrobiopterin and hypertension: more than an emigrating story. Am J Physiol Heart Circ Physiol 300: H715; 2011.

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